Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The role of the locus coeruleus in the development of Parkinson's disease
Autore:
Gesi, M; Soldani, P; Giorgi, FS; Santinami, A; Bonaccorsi, I; Fornai, F;
Indirizzi:
Univ Pisa, Dept Human Morphol & Appl Biol, I-56126 Pisa, Italy Univ Pisa Pisa Italy I-56126 an Morphol & Appl Biol, I-56126 Pisa, Italy INM, Neuromed, Pozzilli, Italy INM Pozzilli ItalyINM, Neuromed, Pozzilli, Italy
Titolo Testata:
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
fascicolo: 6, volume: 24, anno: 2000,
pagine: 655 - 668
SICI:
0149-7634(200008)24:6<655:TROTLC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINERGIC NEUROTOXIN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; NORADRENALINE NEURON SYSTEMS; DOUBLE LABELING TECHNIQUE; EXCITATORY AMINO-ACIDS; CENTRAL-NERVOUS-SYSTEM; SLEEP-WAKING CYCLE; STRIATAL DOPAMINE; SUBSTANTIA-NIGRA; CATECHOLAMINE NEURONS; NORADRENERGIC NEURONS;
Keywords:
locus coeruleus; Parkinson's disease; experimental parkinsonism; norepinephrine; methamphetamine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; DSP-4;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
140
Recensione:
Indirizzi per estratti:
Indirizzo: Fornai, F Univ Pisa, Dept Human Morphol & Appl Biol, Via Roma 55, I-56126 Pisa, Italy Univ Pisa Via Roma 55 Pisa Italy I-56126 5, I-56126 Pisa, Italy
Citazione:
M. Gesi et al., "The role of the locus coeruleus in the development of Parkinson's disease", NEUROSCI B, 24(6), 2000, pp. 655-668

Abstract

In Parkinson's disease, together with the classic loss of dopamine neuronsof the substantia nigra pars compacta, neuropathological studies and biochemical findings documented the occurrence of a concomitant significant celldeath in the locus coeruleus. This review analyzes the latest data obtained from experimental parkinsonism indicating that, the loss of norepinephrine in Parkinson's disease might worsen the dopamine nigrostriatal damage. Within this latter context, basic research provided a new provocative hypothesis on the significance of locus coeruleus in conditioning the natural history of Parkinson's disease. In particular, the loss of a trophic influence of these neurons might be crucial in increasing the sensitivity of nigrostriatal dopamine axons to various neurotoxic insults. In line with this, recently, it has been shown that locus coeruleus activity plays a pivotal role in the expression of various immediate early genes and in inducing the phosphorilation of cyclic adenosine monophosphate response element-binding proteins, suggesting a role of the nucleus in sustaining a protective effect. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 06:52:26