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Titolo:
Species-specific expression of parvalbumin in the entorhinal cortex of theMongolian gerbil: Dependence on local activity but not extrinsic afferents
Autore:
Bender, R; Hoffmann, MC; Frotscher, M; Nitsch, C;
Indirizzi:
Univ Freiburg, Inst Anat 1, D-79104 Freiburg, Germany Univ Freiburg Freiburg Germany D-79104 Anat 1, D-79104 Freiburg, Germany Univ Basel, Inst Anat, CH-4056 Basel, Switzerland Univ Basel Basel Switzerland CH-4056 st Anat, CH-4056 Basel, Switzerland
Titolo Testata:
NEUROSCIENCE
fascicolo: 3, volume: 99, anno: 2000,
pagine: 423 - 431
SICI:
0306-4522(2000)99:3<423:SEOPIT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEIZURE-SENSITIVE GERBIL; ORGANOTYPIC SLICE CULTURES; BINDING PROTEIN CALBINDIN-D28K; RAT HIPPOCAMPUS; GABAERGIC NEURONS; PERFORANT PATH; MERIONES-UNGUICULATUS; NONPYRAMIDAL NEURONS; CEREBRAL-CORTEX; DENTATE GYRUS;
Keywords:
calcium-binding protein; epilepsy; hippocampal formation; Meriones unguiculatus; organotypic slice cultures; seizure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Bender, R Univ Freiburg, Inst Anat 1, Albertstr 17, D-79104 Freiburg, Germany Univ Freiburg Albertstr 17 Freiburg Germany D-79104 rg, Germany
Citazione:
R. Bender et al., "Species-specific expression of parvalbumin in the entorhinal cortex of theMongolian gerbil: Dependence on local activity but not extrinsic afferents", NEUROSCIENC, 99(3), 2000, pp. 423-431

Abstract

Mongolian gerbils are genetically predisposed to develop epileptic seizures in limbic structures. A species-specific property of the Mongolian gerbilis the expression of the calcium-binding protein parvalbumin in the perforant path where it is predominantly concentrated in nerve terminals. To testthe hypothesis that this atypical expression of parvalbumin is induced by seizure-correlated hyperactivity in the entorhinohippocampal loop, we investigated whether it is dependent on extrinsic afferents to the entorhinal cortex. We cultivated organotypic slice cultures of neonate gerbil entorhinalcortex, isolated from all regions it is normally connected with in vivo. In these cultures, parvalbumin-expressing neurons demonstrated their characteristic features like in vivo. Blockade of spontaneous local activity with the sodium-channel blocker tetrodotoxin, however, considerably reduced the number of parvalbumin-expressing neurons in culture. These results indicate that spontaneous local activity, but not activity mediated by extrinsic afferents, is an essential factor for the expression of parvalbumin in the entorhinal cortex of the Mongolian gerbil. (C) 2000 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 08:22:37