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Titolo:
Spinal anandamide inhibits nociceptive transmission via cannabinoid receptor activation in vivo
Autore:
Harris, J; Drew, LJ; Chapman, V;
Indirizzi:
Univ Nottingham, Queens Med Ctr, Sch Med, Sch Biomed Sci, Nottingham NG7 2UH, England Univ Nottingham Nottingham England NG7 2UH , Nottingham NG7 2UH, England
Titolo Testata:
NEUROREPORT
fascicolo: 12, volume: 11, anno: 2000,
pagine: 2817 - 2819
SICI:
0959-4965(20000821)11:12<2817:SAINTV>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED ANTINOCICEPTION; ANTAGONIST; SR141716A; RAT;
Keywords:
anandamide; nociception; rat; spinal cord;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Chapman, V Univ Nottingham, Queens Med Ctr, Sch Med, Sch Biomed Sci, E Floor, Nottingham NG7 2UH, England Univ Nottingham E Floor Nottingham EnglandNG7 2UH UH, England
Citazione:
J. Harris et al., "Spinal anandamide inhibits nociceptive transmission via cannabinoid receptor activation in vivo", NEUROREPORT, 11(12), 2000, pp. 2817-2819

Abstract

The endocannabinoid anandamide has affinity for cannabinoid and vanilloid receptors, which have opposing effects on nociceptive transmission. Effectsof spinal administration of anandamide on innocuous and noxious evoked spinal neuronal responses in non-inflamed and carrageenin-inflamed rats were studied. Anandamide (0.1-50 mu g/50 mu l) had inconsistent effects in non-inflamed rats. Following carrageenin inflammation, anandamide (50 mu g/50 mu l) significantly reduced evoked neuronal responses, C-fibre mediated non-potentiated and post-discharge responses of neurones reduced to 65 +/- 5% and57 +/- 10% of control, respectively. Effects of anandamide were blocked bySR141716A, a selective CB1 receptor antagonist. Spinal SR141716A (0.001-1 ng/50 mu l) alone did not influence neuronal responses in inflamed rats. Spinal anandamide inhibited nociceptive transmission via CB1 receptors; following inflammation there is evidence for a loss of spinal endogenous cannabinoid tone. (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 16:34:33