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Titolo:
Infection by porcine endogenous retrovirus after islet xenotransplantationin SCID mice
Autore:
van der Laan, LJW; Lockey, C; Griffeth, BC; Frasier, FS; Wilson, CA; Onions, DE; Hering, BJ; Long, ZF; Otto, E; Torbett, BE; Salomon, DR;
Indirizzi:
Scripps Clin & Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 Med, La Jolla, CA 92037 USA Genet Therapy Inc, Gaithersburg, MD 20878 USA Genet Therapy Inc Gaithersburg MD USA 20878 c, Gaithersburg, MD 20878 USA US FDA, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA US FDA Bethesda MDUSA 20892 r Biol Evaluat & Res, Bethesda, MD 20892 USA Univ Glasgow, Dept Vet Pathol, Glasgow G61 1QH, Lanark, Scotland Univ Glasgow Glasgow Lanark Scotland G61 1QH ow G61 1QH, Lanark, Scotland Q One Biotech Ltd, Glasgow G20 OXA, Lanark, Scotland Q One Biotech Ltd Glasgow Lanark Scotland G20 OXA 0 OXA, Lanark, Scotland Univ Minnesota, Dept Surg, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 t Surg, Minneapolis, MN 55455 USA
Titolo Testata:
NATURE
fascicolo: 6800, volume: 407, anno: 2000,
pagine: 90 - 94
SICI:
0028-0836(20000907)407:6800<90:IBPERA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-CELLS; ENGRAFTMENT; PIGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Salomon, DR Scripps Clin & Res Inst, Dept Mol & Expt Med, 10550 N Torrey Pines Rd, La Jolla, CA 92037 USA Scripps Clin & Res Inst 10550 N Torrey Pines Rd La Jolla CA USA 92037
Citazione:
L.J.W. van der Laan et al., "Infection by porcine endogenous retrovirus after islet xenotransplantationin SCID mice", NATURE, 407(6800), 2000, pp. 90-94

Abstract

Animal donors such as pigs could provide an alternative source of organs for transplantation. However, the promise of xenotransplantation is offset by the possible public health risk of a cross-species infection(1,2). All pigs contain several copies of porcine endogenous retroviruses (PERV)(3,4), and at least three variants of PERV can infect human cell lines in vitro in co-culture, infectivity and pseudotyping experiments(3,5-7). Thus, if xenotransplantation of pig tissues results in PERV viral replication, there is arisk of spreading and adaptation of this retrovirus to the human host. C-type retroviruses related to PERV are associated with malignancies of haematopoietic lineage cells in their natural hosts(8). Here we show that pig pancreatic islets produce PERV and can infect human cells in culture. After transplantation into NOD/SCID (non-obese diabetic, severe combined immunodeficiency) mice, we detect ongoing viral expression and several tissue compartments become infected. This is the first evidence that PERV is transcriptionally active and infectious cross-species in vivo after transplantation of pig tissues. These results show that a concern for PERV infection risk associated with pig islet xenotransplantation in immunosuppressed human patients may be justified.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 11:09:53