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Titolo:
Increased concentrations of secretory leukocyte protease inhibitor in peritoneal fluid of women with endometriosis
Autore:
Shimoya, K; Moriyama, A; Ogata, I; Nobunaga, T; Koyama, M; Azuma, C; Murata, Y;
Indirizzi:
Osaka Univ, Fac Med, Dept Obstet & Gynecol, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 Gynecol, Suita, Osaka 5650871, Japan Osaka Police Hosp, Dept Obstet & Gynecol, Tennouji Ku, Osaka 5438502, Japan Osaka Police Hosp Osaka Japan 5438502 Tennouji Ku, Osaka 5438502, Japan
Titolo Testata:
MOLECULAR HUMAN REPRODUCTION
fascicolo: 9, volume: 6, anno: 2000,
pagine: 829 - 834
SICI:
1360-9947(200009)6:9<829:ICOSLP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SLPI CONCENTRATIONS; INFERTILE WOMEN; CERVICAL-MUCUS; MACROPHAGES; LEUKOPROTEASE; ELASTASE; QUANTITATION; LOCALIZATION; CELLS;
Keywords:
elastase; endometriosis; peritoneal fluid; peritoneal macrophage; secretory leukocyte protease inhibitor (SLPI);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Shimoya, K Osaka Univ, Fac Med, Dept Obstet & Gynecol, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 50871, Japan
Citazione:
K. Shimoya et al., "Increased concentrations of secretory leukocyte protease inhibitor in peritoneal fluid of women with endometriosis", MOL HUM REP, 6(9), 2000, pp. 829-834

Abstract

Secretory leukocyte protease inhibitor (SLPI) is a potent inhibitor of human leukocyte elastase. We investigated whether SLPI was present in the peritoneal fluid of women with endometriosis and to clarify the role of SLPI inthe pathogenesis of endometriosis. Western blot analyses revealed that SLPI protein was detected as a 12 kDa band in peritoneal fluid. The peritonealfluid concentrations of SLPI, elastase and interleukin-6 were assayed by enzyme-linked immunosorbent assays (ELISA). SLPI concentrations and the SLPI/elastase ratio in the peritoneal fluid of women with endometriosis were higher than in samples from women without endometriosis. There was no significant correlation between concentrations of SLPI and interleukin-6 in the peritoneal fluid. Immunohistochemistry using an anti-SLPI polyclonal antibodyrevealed positive staining in peritoneal macrophages, but not lymphocytes. The present findings suggest that SLPI found in the peritoneal fluid of patients with endometriosis may contribute to the pathogenesis of endometriosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 07:06:09