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Titolo:
CARDIAC INVOLVEMENT IS A CONSTANT FINDING IN ACUTE CHAGAS-DISEASE - ACLINICAL, PARASITOLOGICAL AND HISTOPATHOLOGICAL STUDY
Autore:
PARADA H; CARRASCO HA; ANEZ N; FUENMAYOR C; INGLESSIS I;
Indirizzi:
APARTADO POSTAL 348 MERIDA 5101A VENEZUELA HOSP LUIS RAZETTI BARINAS VENEZUELA UNIV LOS ANDES,CTR CARDIOVASC MERIDA VENEZUELA UNIV LOS ANDES,FAC SCI,CTR PARASITOL RES MERIDA VENEZUELA HOSP UNIV LOS ANDES,DEPT PATHOL MERIDA VENEZUELA
Titolo Testata:
International journal of cardiology
fascicolo: 1, volume: 60, anno: 1997,
pagine: 49 - 54
SICI:
0167-5273(1997)60:1<49:CIIACF>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL DAMAGE;
Keywords:
ACUTE CHAGAS DISEASE; CARDIAC DISEASE; MYOCARDIAL BIOPSY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
H. Parada et al., "CARDIAC INVOLVEMENT IS A CONSTANT FINDING IN ACUTE CHAGAS-DISEASE - ACLINICAL, PARASITOLOGICAL AND HISTOPATHOLOGICAL STUDY", International journal of cardiology, 60(1), 1997, pp. 49-54

Abstract

During the last 8 years 58 acute cases of Chagas' disease were studied. Patients from an endemic area of the state of Barinas, Venezuela, showed fever (98%) and circulating forms of T. cruzi (100%), and were treated with oral benznidazole. The recorded mortality was 8.6%. Acute myocarditis was constantly found either in myocardial biopsies or at necropsy, even in patients without any other sign of cardiac compromise(36%), which was detected by chest X-ray in 58%, by 2D echocardiography in 52%, by resting ECG in 41% and by clinical findings in 27.5% of the patients. Cardiomegaly was due to pericardial effusion rather thanventricular dilatation in most instances. Treatment eliminated parasitemia but negativized serology in only 20% of patients. It also appeared to have little influence on the ongoing myocarditic process, emphasizing the need for better therapeutic schedules, able to avoid or control the early appearance of immunologic mechanisms and microcirculatory damage involved in the future development of chronic chagasic myocarditis. (C) 1997 Elsevier Science Inland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 17:18:39