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Titolo:
ENDOTHELIN MAY BE PATHOGENIC IN SYSTEMIC-SCLEROSIS OF THE HEART
Autore:
KAZZAM E; WALDENSTROM A; HEDNER T; HEDNER J; CAIDAHL K;
Indirizzi:
UMEA UNIV HOSP,DEPT INTERNAL MED,DIV CARDIOL S-90185 UMEA SWEDEN SAHLGRENS UNIV HOSP,DEPT CLIN PHARMACOL S-41345 GOTHENBURG SWEDEN SAHLGRENS UNIV HOSP,DEPT CLIN PHYSIOL S-41345 GOTHENBURG SWEDEN
Titolo Testata:
International journal of cardiology
fascicolo: 1, volume: 60, anno: 1997,
pagine: 31 - 39
SICI:
0167-5273(1997)60:1<31:EMBPIS>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATRIAL-NATRIURETIC-PEPTIDE; LEFT-VENTRICULAR FUNCTION; PLASMA ENDOTHELIN; ECHOCARDIOGRAPHIC MEASUREMENTS; NONINVASIVE ASSESSMENT; MYOCARDIAL-ISCHEMIA; SCLERODERMA; FAILURE; VASOCONSTRICTOR; RELEASE;
Keywords:
ATRIAL NATRIURETIC PEPTIDE; ECHOCARDIOGRAPHY; ENDOTHELIN; SYSTEMIC SCLEROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
E. Kazzam et al., "ENDOTHELIN MAY BE PATHOGENIC IN SYSTEMIC-SCLEROSIS OF THE HEART", International journal of cardiology, 60(1), 1997, pp. 31-39

Abstract

We evaluated 30 consecutive patients and 48 age- and sex-matched controls to explore the possibility of a pathogenic contribution by plasmaendothelin-1 in the cardiac expression of systemic sclerosis. Venous plasma endothelin-1 was measured by radio-immunoassay and left ventricular function by echocardiography. The patient group had elevated plasma endothelin-1 (2.6+/-0.2 vs. 1.8+/-0.1 pmol/l, P<0.001), but endothelin-1 was not related to age, heart rate, blood pressure, total peripheral resistance, disease duration or systemic sclerosis score. Endothelin-1 was related to left ventricular hypertrophy in terms of septal thickness (r=0.33, P<0.01) and left ventricular mass index (r=0.32, P<0.01). Plasma endothelin-1 was further related to measures indicating reduced left ventricular filling; left atrial emptying index (r=-0.50, P<0.0005), the first third tilling fraction (r=-0.31, P<0.05) and the time velocity integral of Doppler early/late filling velocity (r=-0.40, P<0.001). Furthermore, circulating endothelin-1 was related to impaired left Ventricular contractility as estimated by pre-ejection period/left ventricular ejection time (r=0.32, P<0.01) and end-systolic wallstress/volume index (r=-0.30, P<0.05). We conclude that plasma endothelin-1 is elevated in relation to the degree of left ventricular hypertrophy, diastolic dysfunction and impaired contractility in systemic sclerosis. It may be of pathogenic importance to the cardiac involvement in systemic sclerosis which is not mediated via an increase in systemic blood pressure. It is not yet clear whether our findings are exclusive to systemic sclerosis patients or represent a generalized phenomenon in patients with impaired left ventricular function. (C) 1997 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 19:56:01