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Titolo:
Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with severe preeclampsia
Autore:
Yoshimura, T; Yoshimura, M; Tabata, A; Shimasaki, Y; Nakayama, M; Miyamoto, Y; Saito, Y; Nakao, K; Yasue, H; Okamura, H;
Indirizzi:
Kumamoto Univ, Sch Med, Dept Obstet & Gynecol, Kumamoto 8608556, Japan Kumamoto Univ Kumamoto Japan 8608556 & Gynecol, Kumamoto 8608556, Japan Kumamoto Univ, Sch Med, Dept Cardiovasc Med, Kumamoto 8608556, Japan Kumamoto Univ Kumamoto Japan 8608556 iovasc Med, Kumamoto 8608556, Japan Kyoto Univ, Grad Sch Med, Dept Med & Clin Sci, Kyoto, Japan Kyoto Univ Kyoto Japan Grad Sch Med, Dept Med & Clin Sci, Kyoto, Japan
Titolo Testata:
JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION
fascicolo: 4, volume: 7, anno: 2000,
pagine: 238 - 241
SICI:
1071-5576(200007/08)7:4<238:AOTMGV>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREGNANCY; WOMEN; HYPERTENSION; ANGIOTENSINOGEN; POLYMORPHISM; ECLAMPSIA; ETIOLOGY;
Keywords:
nitric oxide; endothelial nitric oxide synthase; preeclampsia; genetics; polymorphism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Yoshimura, T Kumamoto Univ, Sch Med, Dept Obstet & Gynecol, Honjo 1-1-1, Kumamoto 8608556, Japan Kumamoto Univ Honjo 1-1-1 Kumamoto Japan 8608556 8556, Japan
Citazione:
T. Yoshimura et al., "Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with severe preeclampsia", J SOC GYN I, 7(4), 2000, pp. 238-241

Abstract

OBJECTIVES: A large number of studies suggest that abnormalities in nitricoxide (NO) synthesis may contribute to the development of preeclampsia. Werecently identified a variant within exon 7 of the endothelial NO synthase(eNOS) gene: G to T conversion at nucleotide position 894 resulting in replacement of glutamic acid with aspartic acid at codon 298 (Glu298Asp). We analyzed the association between the Glu298Asp eNOS gene variant and preeclampsia. STUDY DESIGN: The study included 152 preeclampsia patients (35 mild, 80 severe, and 37 superimposed) and 170 control subjects. Screening for the Glu298Asp eNOS gene variant was carried out by analysis of polymerase chain reaction-restriction fragment length polymorphism. RESULTS: The frequency of the Glu298Asp variant was significantly higher in the severe preeclampsia group (28.8%) than in the control (14.1%; p < .01), superimposed preeclampsia (8.1%, p < .01), and mild preeclampsia (11.4% p < .01) groups. CONCLUSIONS: We conclude that the presence of the Glu298Asp eNOS gene could be a marker of increased risk of developing severe preeclampsia. (J Soc Gynecol Investig 2000;7:238-41) Copyright (C) 2000 by the Society for Gynecologic Investigation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:31:04