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Titolo:
Activation of the hypothalamic-pituitary-adrenal axis with repetitive umbilical cord occlusion in the preterm ovine fetus
Autore:
Green, LR; Kawagoe, Y; Fraser, M; Challis, JRG; Richardson, BS;
Indirizzi:
Univ Western Ontario, Lawson Res Inst, Dept Obstet & Gynecol, MRC,Grp Fetal & Neonatal Hlth & Dev, London, ON, Canada Univ Western Ontario London ONCanada tal Hlth & Dev, London, ON, Canada Univ Western Ontario, Lawson Res Inst, Dept Physiol, MRC,Grp Fetal & Neonatal Hlth & Dev, London, ON, Canada Univ Western Ontario London ON Canada tal Hlth & Dev, London, ON, Canada Univ Toronto, Fac Med, Dept Physiol, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 ysiol, Toronto, ON M5S 1A8, Canada
Titolo Testata:
JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION
fascicolo: 4, volume: 7, anno: 2000,
pagine: 224 - 232
SICI:
1071-5576(200007/08)7:4<224:AOTHAW>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RIBONUCLEIC-ACID; FETAL SHEEP; BLOOD-FLOW; VARIABLE DECELERATIONS; DEVELOPMENTAL-CHANGES; PROLONGED HYPOXEMIA; ENDOCRINE RESPONSES; SUSTAINED HYPOXEMIA; LATE-GESTATION; PROOPIOMELANOCORTIN;
Keywords:
umbilical cord occlusion; ovine; fetus; ACTH; cortisol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Green, LR 887F Princess Anne Hosp, Ctr Fetal Origins Adult Dis, Coxford Rd, Southampton SO16 5YA, Hants, England 887F Princess Anne Hosp Coxford Rd Southampton Hants England SO16 5YA
Citazione:
L.R. Green et al., "Activation of the hypothalamic-pituitary-adrenal axis with repetitive umbilical cord occlusion in the preterm ovine fetus", J SOC GYN I, 7(4), 2000, pp. 224-232

Abstract

OBJECTIVE: To determine whether repeated hypoxic insults with umbilical cord occlusion over 4 days will lead to activation of the hypothalamic-pituitary-adrenal (HPA) axis altered adrenocortical responsiveness in the pretermovine fetus. METHODS: Umbilical cord occlusions of 90 seconds duration were performed every 30 minutes for 3 to 5 hours each day (experimental group n = 7, control group n = 7; at 112-116 days' gestation, term = 147 days). Arterial bloodwas sampled at predetermined times for blood gases and pH, plasma ACTH, and cortisol. Pituitary proopiomelanocortin (POMC) and glucocorticoid receptor (GR) mRNA also were localized and quantified by in situ hybridization. RESULTS: During umbilical cord occlusions fetal arterial oxygen pressure (approximately 17 mmHg) and pH (approximately 0.05) decreased, and carbon dioxide pressure increased (approximately 8 mmHg) as measured on days 1 and 4, but with no cumulative blood gas or pH change over successive occlusions for any of the 4 study days. Plasma ACTH increased, as measured after cord occlusion and over the course of successive cord occlusions on days 1 and 4, and returned to control values by the next day. The cumulative increase in ACTH was much less on day 4 than day 1 (15 +/- 3 compared with 101 +/- 25pg/mL, P < .05). Plasma cortisol increased, as measured after cord occlusion and over the course of successive cord occlusions on day 4 only (2.7 +/-0.4 to 4.7 +/- 0.3 ng/mL, P < .05). POMC mRNA increased 2.5-fold in the pars distalis of the pituitaries from cord occlusion compared to control fetuses, but was unchanged in the pars intermedia. GR mRNA, which was detected in the pars distalis only, was unaltered. CONCLUSION: Repetitive umbilical cord occlusion in the preterm ovine fetusresulted in the activation of the HPA axis, with increased adrenocortical responsiveness over time, and involved differential regulation of POMC mRNAexpression in the pars distalis and pars intermedia of the pituitary, but with no change in GR. (J Soc Gynecol Investig 2000;7;224-32) Copyright (C) 2000 by the Society for Gynecologic Investigation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 13:24:22