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Titolo:
PLEURAL MESOTHELIOMA MIMICS THE INTEGRIN PROFILE OF ACTIVATED, SESSILE RATHER THAN DETACHED MESOTHELIAL CELLS
Autore:
BARTH TFE; BRUDERLEIN S; RINALDI N; MECHTERSHEIMER G; MOLLER P;
Indirizzi:
UNIV ULM,INST PATHOL,ALBERT EINSTEIN ALLEE 11 D-89081 ULM GERMANY UNIV ULM,INST PATHOL D-89081 ULM GERMANY UNIV HEIDELBERG,DEPT INTERNAL MED 5 HEIDELBERG GERMANY UNIV HEIDELBERG,INST PATHOL D-6900 HEIDELBERG GERMANY
Titolo Testata:
International journal of cancer
fascicolo: 1, volume: 72, anno: 1997,
pagine: 77 - 86
SICI:
0020-7136(1997)72:1<77:PMMTIP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRACELLULAR-MATRIX; EXPRESSION; PROTEINS; ADHESION; SURVIVAL; ANTIGENS; RECEPTOR; FAMILY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
T.F.E. Barth et al., "PLEURAL MESOTHELIOMA MIMICS THE INTEGRIN PROFILE OF ACTIVATED, SESSILE RATHER THAN DETACHED MESOTHELIAL CELLS", International journal of cancer, 72(1), 1997, pp. 77-86

Abstract

Mesothelial cells (MC) form a polarized monolayer lining serosal cavities. During serositis, the MC lining undergoes hyperplasia, and MC are shed into effusions. During these processes, contact with basement membrane and, ultimately, neighboring cells is at least temporarily lost, suggesting regulated alterations in cell/matrix and cell/cell adhesion. Such interactions are primarily mediated by integrins. Malignant mesothelioma has a growth pattern characterized by lateral, limited invasive but contiguous spread. During serositis, activated MC, both sessile and detached, expressed an extended spectrum of beta(1), beta(3) and beta(4) integrins compared with resting MC, as shown by immunohistology. Malignant mesothelioma had an integrin repertoire and a subcellular distribution resembling that of activated sessile rather than floating MC. In vitro, MC exposed a more comprehensive pattern of integrins than that of the newly established mesothelioma cell lines ME-HD-1 and ME-HD-2, as shown by flow cytometry. MC consistently adhered better than mesothelioma cells to laminin, tenascin, fibronectin and collagen type IV. Adhesion of MC and mesothelioma cells to these matrix proteins was, at least in part, mediated via beta(1) integrins. The different integrin profiles and adhesion properties of cultured MC and mesothelioma cells may reflect a limited functional differentiation of the latter. (C) 1997 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 13:58:38