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Titolo:
Increased sodium-proton antiporter activity in patients with obstructive sleep apnoea
Autore:
Tepel, M; Sanner, BM; Van Der Giet, M; Zidek, W;
Indirizzi:
Ruhr Univ Bochum, Marienhosp Herne, Univ Klin, Med Klin 1, D-44625 Herne, Germany Ruhr Univ Bochum Herne Germany D-44625 ed Klin 1, D-44625 Herne, Germany
Titolo Testata:
JOURNAL OF SLEEP RESEARCH
fascicolo: 3, volume: 9, anno: 2000,
pagine: 285 - 291
SICI:
0962-1105(200009)9:3<285:ISAAIP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORAL GLUCOSE CHALLENGE; H+ EXCHANGER ACTIVITY; ESSENTIAL-HYPERTENSION; NA+/H+ EXCHANGE; IMMORTALIZED LYMPHOBLASTS; RENAL-FAILURE; APNEA; PLATELET; KINASE; HEMODIALYSIS;
Keywords:
fluorescent dye; lymphocytes; obstructive sleep apnoea; sodium-proton antiporter;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Tepel, M Ruhr Univ Bochum, Marienhosp Herne, Univ Klin, Med Klin 1, Holkeskampring 40, D-44625 Herne, Germany Ruhr Univ Bochum Holkeskampring 40 Herne Germany D-44625 Germany
Citazione:
M. Tepel et al., "Increased sodium-proton antiporter activity in patients with obstructive sleep apnoea", J SLEEP RES, 9(3), 2000, pp. 285-291

Abstract

Cytosolic pH (pH(i)) and the activity of the sodium-proton antiporter (Na+/H+ antiporter) were measured in lymphocytes from 22 patients with obstructive sleep apnoea and from 24 age-matched healthy subjects (Controls). The cellular Na+/H+ antiporter was measured spectrophotometrically using a pH-sensitive fluorescent dye after intracellular acidification using sodium propionate. Resting pH(i) was similar in lymphocytes from patients with obstructive sleep apnoea and from controls (7.36 +/- 0.20, n=22; vs. 7.35 +/- 0.19, n=24; mean +/- SD). The Na+/H+ antiporter activity was significantly higher in patients with obstructive sleep apnoea than in controls (11.87 +/- 3.26 x 10(-3) pH(i)/s vs. 4.38 +/- 1.40 x 10(-3) pH(i)/s; P < 0.0001). The apparent affinity of the Na+/H+ antiporter was not significantly different between the groups (6.90 +/- 0.23 vs. 6.87 +/- 0.20). In patients with obstructive sleep apnoea the activity of the Na+/H+ antiporter remained stable during the night. The activity of the Na+/H+ antiporter was 13.49 +/- 4.80 x 10(-3) pH(i)/s at 20.00 and 13.26 +/- 6.13 x 10(-3) pH(i)/s at 02.00. From the present results it is concluded that an increased cellular Na+/H+ antiporter activity may be a genetic marker for patients who are predisposed to obstructive sleep apnoea.

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Documento generato il 19/01/20 alle ore 01:23:40