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Titolo:
Impaired autoregulation of cerebral blood flow in an experimental model oftraumatic brain injury
Autore:
Engelborghs, K; Haseldonckx, M; Van Reempts, J; Van Rossem, K; Wouters, L; Borgers, M; Verlooy, J;
Indirizzi:
Janssen Res Fdn, Dept Life Sci, B-2340 Beerse, Belgium Janssen Res Fdn Beerse Belgium B-2340 t Life Sci, B-2340 Beerse, Belgium Univ Antwerp Hosp, Dept Neurosurg, Antwerp, Belgium Univ Antwerp Hosp Antwerp Belgium osp, Dept Neurosurg, Antwerp, Belgium
Titolo Testata:
JOURNAL OF NEUROTRAUMA
fascicolo: 8, volume: 17, anno: 2000,
pagine: 667 - 677
SICI:
0897-7151(200008)17:8<667:IAOCBF>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLOSED-HEAD-INJURY; INTRACRANIAL-PRESSURE; CEREBROVASCULAR RESPONSES; ACUTE HYPERTENSION; ANESTHETIZED RATS; AUTO-REGULATION; ISOFLURANE; CATS; HYPOTENSION; CIRCULATION;
Keywords:
autoregulation; cerebral blood flow; closed head injury; hypotension; rat; traumatic brain injury;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Van Rossem, K Janssen Res Fdn, Dept Life Sci, Turnhoutseweg 30, B-2340 Beerse, Belgium Janssen Res Fdn Turnhoutseweg 30 Beerse Belgium B-2340 gium
Citazione:
K. Engelborghs et al., "Impaired autoregulation of cerebral blood flow in an experimental model oftraumatic brain injury", J NEUROTRAU, 17(8), 2000, pp. 667-677

Abstract

In order to study the pathophysiology and the intracranial hemodynamics oftraumatic brain injury, we have developed a modified closed-head injury model of impact-acceleration that expresses several features of severe head injury in humans, including acute and long-lasting intracranial hypertension, diffuse axonal injury, neuronal necrosis, bleeding, and edema. In view ofthe clinical relevance of impaired autoregulation of cerebral blood flow after traumatic brain injury, and aiming at further characterization of the model, we investigated the autoregulation efficiency 24 h after experimental closed-head injury. Cortical blood flow was continuously monitored with alaser-Doppler flowmeter, and the mean arterial blood pressure was progressively decreased by controlled hemorrhage. Relative laser-Doppler flow was plotted against the corresponding mean arterial blood pressure, and a two-line segmented model was applied to determine the break point and slopes of the autoregulation curves. The slope of the curve at the right hand of the break point was significantly increased in the closed head injury group (0.751 +/- 0.966%/mm Hg versus -0.104 +/- 0.425%/mm Hg,p = 0.028). The break point tended towards higher values in the closed head injury group (62.2 +/- 20.8 mm Hg versus 46.9 +/- 12.7 mm Hg; mean a SD, p = 0.198). It is concluded that cerebral autoregulation in this modified closed head injury model is impaired 24 h after traumatic brain injury. This finding, in addition to other characteristic features of severe head injury established earlier in this model, significantly contributes to its clinical relevance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:39:56