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Titolo:
Alcohol consumption by C57BL/6 mice is associated with depletion of lymphoid cells from the gut-associated lymphoid tissues and altered resistance tooral infections with Salmonella typhimurium
Autore:
Sibley, D; Jerrells, TR;
Indirizzi:
Louisiana State Univ, Med Ctr, Dept Cellular Biol & Anat, Shreveport, LA 71130 USA Louisiana State Univ Shreveport LA USA 71130 at, Shreveport, LA 71130 USA Univ Nebraska, Med Ctr, Dept Pathol & Microbiol, Omaha, NE USA Univ Nebraska Omaha NE USA d Ctr, Dept Pathol & Microbiol, Omaha, NE USA
Titolo Testata:
JOURNAL OF INFECTIOUS DISEASES
fascicolo: 2, volume: 182, anno: 2000,
pagine: 482 - 489
SICI:
0022-1899(200008)182:2<482:ACBCMI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYCOBACTERIUM-AVIUM COMPLEX; TUMOR-NECROSIS-FACTOR; IFN-GAMMA; GASTROINTESTINAL-TRACT; INTRACELLULAR BACTERIA; ETHANOL-CONSUMPTION; CELLULAR-IMMUNITY; T-LYMPHOCYTES; RESPONSES; CHALLENGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Jerrells, TR Omaha VA Med Ctr, Res Serv 151, 4101 Woolworth Ave, Omaha, NE68105 USA Omaha VA Med Ctr 4101 Woolworth Ave Omaha NE USA 68105 05 USA
Citazione:
D. Sibley e T.R. Jerrells, "Alcohol consumption by C57BL/6 mice is associated with depletion of lymphoid cells from the gut-associated lymphoid tissues and altered resistance tooral infections with Salmonella typhimurium", J INFEC DIS, 182(2), 2000, pp. 482-489

Abstract

Studies were done to test whether ethanol (ETOH) consumption alters resistance to mucosal and systemic infections by Salmonella typhimurium. S. typhimurium-immune and -nonimmune mice were fed 1 of 3 diets (an ETOH-containingliquid diet, an isocaloric liquid diet equal in volume to that of the ETOH-treated group, or laboratory chow) in a pair-feeding design and were infected orally or intravenously with S. typhimurium. The number of bacteria in spleen and liver and the effect of ETOH feeding and infection on the numberof lymphoid cells in the gut-associated lymphoid tissues (GALT) were determined, ETOH feeding resulted in profound loss of GALT lymphoid cells and anincreased number of Salmonella organisms in the intestines, liver, and spleen of infected nonimmune, but not of immune, mice. These data show that ETOH consumption in this model impairs host defense mechanisms that control mucosal infections and inhibits the mechanisms that control levels of bacteria in the central organs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 17:30:36