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Titolo:
Genetic variations of the apolipoprotein E gene determine the plasma triglyceride levels after heart transplantation
Autore:
Gonzalez-Amieva, A; Lopez-Miranda, J; Fuentes, F; Castro, P; Marin, C; Lopez-Granados, A; Valles, F; Jimenez, FP;
Indirizzi:
Hosp Univ Reina Sofia, Unidad Lipidos & Arteriosclerosis, Cordoba 14004, Spain Hosp Univ Reina Sofia Cordoba Spain 14004 clerosis, Cordoba 14004, Spain Hosp Univ Reina Sofia, Serv Cardiol, Cordoba 14004, Spain Hosp Univ Reina Sofia Cordoba Spain 14004 Cardiol, Cordoba 14004, Spain
Titolo Testata:
JOURNAL OF HEART AND LUNG TRANSPLANTATION
fascicolo: 8, volume: 19, anno: 2000,
pagine: 765 - 770
SICI:
1053-2498(200008)19:8<765:GVOTAE>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; LONG-TERM SURVIVORS; E POLYMORPHISM; CARDIAC TRANSPLANTATION; MYOCARDIAL-INFARCTION; LIPASE ACTIVITY; CYCLOSPORINE; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; ATHEROSCLEROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Jimenez, FP Hosp Univ Reina Sofia, Unidad Lipidos & Arteriosclerosis, Avenida MenendezPidal S-N, Cordoba 14004, Spain Hosp Univ Reina Sofia Avenida Menendez Pidal S-N Cordoba Spain 14004
Citazione:
A. Gonzalez-Amieva et al., "Genetic variations of the apolipoprotein E gene determine the plasma triglyceride levels after heart transplantation", J HEART LUN, 19(8), 2000, pp. 765-770

Abstract

Objectives: To study whether the presence of the polymorphism in the apolipoprotein E (apo E) gene influences the lipid profile in heart-transplant recipients. Methods: A cohort of 103 recipients of heart transplant (93 men and 10 women, with a mean age of 47 +/- 13 years) under triple immunosuppressive therapy were submitted to a genetic study of the apo E gene region. Anthropometric and analytical data, including lipid profile and arterial blood pressure were collected prior to transplantation and 3, 6, 12, and 24 months afterit. Results: 65 subjects present the genotype E3E3, 27 the genotype E3E4, 6 the genotype E2E3, and 5 the genotype E2E4. Carriers of the E2 allele (that is, genotypes E3E2 and E4E2) had higher total plasma triglyceride (TG) levels after 3 months (3.37 +/- 1.88 nmo/liter p < 0.001) and after 1 year of transplantation (3.13 +/- 1.77 mmol/liter p < 0.05) than the other genotypes. There were no differences in the plasma levels of total cholesterol (TC), LDL-cholesterol (LDL-C), and HDL-cholesterol (HDL-C). Multiple regression analysis revealed that the apoprotein E gene polymorphism determines 5% (p =0.0425) and age 8.7% (p < 0.009) of the variants in TG levels. Conclusion: The presence of the E2 allele in heart-transplant recipients produces a greater rise in total TG plasma levels than the other genotypes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:16:27