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Titolo:
Macrophage-tropic HIV induces and exploits dendritic cell chemotaxis
Autore:
Lin, CL; Sewell, AK; Gao, GEF; Whelan, KT; Phillips, RE; Austyn, JM;
Indirizzi:
Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Med, Oxford OX3 9DU, England Univ Oxford Oxford England OX3 9DU ept Clin Med, Oxford OX3 9DU, England Univ Oxford, John Radcliffe Hosp, Nuffield Dept Surg, Oxford OX3 9DU, England Univ Oxford Oxford England OX3 9DU ld Dept Surg, Oxford OX3 9DU, England Harvard Univ, Howard Hughes Med Inst, Struct Mol Biol Lab, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA Harvard Univ Cambridge MA USA 02138 ellular Biol, Cambridge, MA 02138 USA
Titolo Testata:
JOURNAL OF EXPERIMENTAL MEDICINE
fascicolo: 4, volume: 192, anno: 2000,
pagine: 587 - 593
SICI:
0022-1007(20000821)192:4<587:MHIAED>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; CYTOTOXIC T-LYMPHOCYTES; CHEMOKINE RECEPTOR; PRIMARY INFECTION; LANGERHANS CELLS; BETA-CHEMOKINES; SYNCYTIA; CXCR4; CCR5; INDIVIDUALS;
Keywords:
dendritic cell; HIV; chemotaxis; chemokine; CCR5;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Sewell, AK Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Med, Level7, Oxford OX3 9DU, England Univ Oxford Level 7 Oxford England OX3 9DU rd OX3 9DU, England
Citazione:
C.L. Lin et al., "Macrophage-tropic HIV induces and exploits dendritic cell chemotaxis", J EXP MED, 192(4), 2000, pp. 587-593

Abstract

Immature dendritic cells (iDCs) express the CC chemokine receptor (CCR)5, which promotes chemotaxis toward the CC chemokines regulated on activation,normal T cell expressed and secreted (RANTES), macrophage inflammatory protein (MIP)-1 alpha, and MIP-1 beta. By contrast, mature DCs downregulate CCR5 but upregulate CXC chemokine receptor (CXCR)4, and as a result exhibit enhanced chemotaxis toward stromal cell-derived factor (SDF)-1 alpha. CCR5, and CXCR4 also function as coreceptors for macrophage-tropic (M-tropic) andT cell-tropic (T-tropic) human immunodeficiency virus (HIV)-1, respectively. Here, we demonstrate chemotaxis of iDCs toward M-tropic (R5) but not T-tropic (X4) HIV-1. Furthermore, preexposure to M-tropic HIV-1 or its recombinant envelope protein prevents migration toward CCR5 ligands. The migrationof iDCs toward M-tropic HIV-1 may enhance formation of DC-T cell syncytia,thus promoting viral production and destruction of both DC and T helper lymphocytes. Therefore, disturbance of DC chemotaxis by HIV-1 is likely to contribute to immunosuppression in primary infection and AIDS. In addition, migration of iDCs toward HIV-1 may aid the capture of R5 HIV-1 virions by the abundant DC cell surface protein DC-specific intercellular adhesion molecule (ICAM)3-grabbing nonintegrin (DC-SIGN). HIV-1 bound to DC cell-specificDC-SIGN retains the ability to infect replication-permissive T cells in trans for several days. Consequently, recruitment of DC by HIV-1 could combine with the ability of DC-SIGN to capture and transmit the virus to T cells,and so facilitate dissemination of virus within an infected individual.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 10:23:49