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Titolo:
Cross-talk between two cysteine protease families: Activation of caspase-12 by calpain in apoptosis
Autore:
Nakagawa, T; Yuan, JY;
Indirizzi:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ed, Dept Cell Biol, Boston, MA 02115 USA
Titolo Testata:
JOURNAL OF CELL BIOLOGY
fascicolo: 4, volume: 150, anno: 2000,
pagine: 887 - 894
SICI:
0021-9525(20000821)150:4<887:CBTCPF>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-DEATH; NEUTRAL PROTEASE; CEREBRAL-ISCHEMIA; BCL-X; CALCIUM; INHIBITOR; CLEAVAGE; DISEASE; INVOLVEMENT; EXPRESSION;
Keywords:
calcium; Alzheimer's disease; Bcl-xL; endoplasmic reticulum; ER stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Yuan, JY Harvard Univ, Sch Med, Dept Cell Biol, 240 Longwood Ave, Boston, MA 02115 USA Harvard Univ 240 Longwood Ave Boston MA USA 02115 n, MA 02115 USA
Citazione:
T. Nakagawa e J.Y. Yuan, "Cross-talk between two cysteine protease families: Activation of caspase-12 by calpain in apoptosis", J CELL BIOL, 150(4), 2000, pp. 887-894

Abstract

Calpains and caspases are two cysteine protease families that play important roles in regulating pathological cell death. Here, we report that m-calpain may be responsible for cleaving procaspase-12, a caspase localized in the ER, to generate active caspase-12. In addition, calpain may be responsible for cleaving the loop region in Bcl-xL and, therefore, turning an antiapoptotic molecule into a proapoptotic molecule. We propose that disturbance to intracellular calcium storage as a result of ischemic injury or amyloid beta peptide cytotoxicity may induce apoptosis through calpain-mediated caspase-12 activation and Bcl-xL inactivation. These data suggest a novel apoptotic pathway involving calcium-mediated calpain activation and cross-talksbetween calpain and caspase families.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 22:48:35