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Titolo:
Leptin plasma concentrations are dependent on body fat distribution in obese patients
Autore:
Minocci, A; Savia, G; Lucantoni, R; Berselli, ME; Tagliaferri, M; Calo, G; Petroni, ML; de Medici, C; Viberti, GC; Liuzzi, A;
Indirizzi:
Osped San Giuseppe, IRCCS, Ist Auxol Italiano, Div endocrinol & Metab Dis,I-28044 Verbania, Italy Osped San Giuseppe Verbania Italy I-28044 ab Dis,I-28044 Verbania, Italy Osped San Giuseppe, IRCCS, Ist Auxol Italiano, Dept Nutr, I-28044 Verbania, Italy Osped San Giuseppe Verbania Italy I-28044 Nutr, I-28044 Verbania, Italy Osped San Giuseppe, IRCCS, Ist Auxol Italiano, Lab Chem Chem, I-28044 Verbania, Italy Osped San Giuseppe Verbania Italy I-28044 Chem, I-28044 Verbania, Italy Guys Hosp, KCL, Metab Med Unit, London SE1 9RT, England Guys Hosp LondonEngland SE1 9RT Metab Med Unit, London SE1 9RT, England IRCCS, Ist Auxol Italiano, Diabet Res Lab Sam Michele, Milan, Italy IRCCSMilan Italy ol Italiano, Diabet Res Lab Sam Michele, Milan, Italy
Titolo Testata:
INTERNATIONAL JOURNAL OF OBESITY
fascicolo: 9, volume: 24, anno: 2000,
pagine: 1139 - 1144
SICI:
0307-0565(200009)24:9<1139:LPCADO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
VISCERAL ADIPOSE-TISSUE; SERUM LEPTIN; OB GENE; CIRCULATING LEPTIN; GENDER DIFFERENCES; INSULIN; WOMEN; EXPRESSION; ASSOCIATIONS; SECRETION;
Keywords:
leptin; fat distribution; ultrasound; obesity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Liuzzi, A Osped San Giuseppe, IRCCS, Ist Auxol Italiano, Div endocrinol & Metab Dis,I-28044 Verbania, Italy Osped San Giuseppe Verbania Italy I-28044 8044 Verbania, Italy
Citazione:
A. Minocci et al., "Leptin plasma concentrations are dependent on body fat distribution in obese patients", INT J OBES, 24(9), 2000, pp. 1139-1144

Abstract

AIM: To evaluate whether fat distribution plays a role in determining serum leptin concentrations. PATIENTS AND METHODS: One-hundred and forty-seven obese patients, 77 malesand 70 females, aged 45.1 +/- 13.2 y (mean +/- s.d.; range 21 - 73 y), with body mass index (BMI) ranging from 30 to 55 kg/m(2) (mean 42.3 +/- 5.9). Ultrasound assessment of the thickness of subcutaneous and preperitoneal far was carried out and calculation of their ratio as abdominal fat index (AFI), waist-hip ratio (WHR), body composition by bioelectrical impedance to evaluate the percentage of fat mass (FM%) and total amount of fat (FMKg) were also determined. Plasma leptin was measured by radio immune assay (RIA). RESULTS: In the whole group of patients, serum leptin concentrations were 37.2 +/- 18.4 ng/ml (range 6-101.3 ng/ml); in spite of BMI values not beingsignificantly different, women had leptin values significantly higher (47.4 +/- 17.4 ng/ml) (P < 0.01) than males (28.1 +/- 15.1 ng/ml), also after correction for fat mass. The mean thickness of abdominal subcutaneous fat was 33.7 +/- 12.9 mm and it was significantly (P < 0.001) higher in female (40.9 +/- 10.6 mm) than in male (27.1 +/- 11.2 mm) patients; preperitoneal thickness was 22.9 +/- 7.1 mm, with significantly (P < 0.05) higher values inmales (24.2 +/- 6.8 mm) than in females (21.7 +/- 7.3 mm). Accordingly, AFI tin all patients 0.84 +/- 0.6) was significantly higher in males (1.09 +/- 0.6) than in females (0.56 +/- 0.2). In the overall population, leptin concentrations were directly and significantly related to subcutaneous but not preperitoneal fat; they showed a strong inverse relationship with AFI andWHR, When the results were evaluated dividing the patients according to gender, subcutaneous fat thickness showed a stronger association with leptin levels in males than in females, whereas no association was found with preperitoneal fat thickness. Leptin and AFI values were significantly related only in men. WHR values were not correlated with leptin concentrations in either sex. When fat mass was added to the model, subcutaneous fat thickness,AFI and WHR remained independently associated with leptin concentrations. Age and diabetes did not influence these measures. CONCLUSIONS: Fat distribution contributes to the variability in serum leptin in obese patients. In particular, subcutaneous abdominal fat is a determinant of leptin concentration, also independently of the amount of fat mass, whereas the contribution of preperitoneal visceral fat is not significant.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 05:08:38