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Titolo:
Atherosclerosis-induced chronic arterial insufficiency causes clitoral cavernosal fibrosis in the rabbit
Autore:
Park, K; Tarcan, T; Goldstein, I; Siroky, MB; Krane, RJ; Azadzoi, KM;
Indirizzi:
Boston VA Med Ctr, Boston, MA 02130 USA Boston VA Med Ctr Boston MA USA 02130 on VA Med Ctr, Boston, MA 02130 USA Boston Univ, Sch Med, Dept Urol, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 Sch Med, Dept Urol, Boston, MA 02118 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
fascicolo: 2, volume: 12, anno: 2000,
pagine: 111 - 116
SICI:
0955-9930(200004)12:2<111:ACAICC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEXUAL DYSFUNCTION; SMOOTH-MUSCLE; ANIMAL-MODEL; ERECTILE DYSFUNCTION; TISSUE; WOMEN;
Keywords:
clitoris; atherosclerosis; ischemia; smooth muscle; fibrosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Azadzoi, KM Boston VA Med Ctr, 150 S Huntington Ave, Boston, MA 02130 USA Boston VA Med Ctr 150 S Huntington Ave Boston MA USA 02130 USA
Citazione:
K. Park et al., "Atherosclerosis-induced chronic arterial insufficiency causes clitoral cavernosal fibrosis in the rabbit", INT J IMPOT, 12(2), 2000, pp. 111-116

Abstract

In our previous studies we found that aging-associated fibrosis of clitoral cavernosal tissue correlated with the prevalence of cardiovascular disease in elderly women. The aim of this study was to determine specifically, arterial insufficiency-relate structural changes of clitoral cavernosal tissue in a rabbit model. New Zealand white female rabbits were divided into clitoral cavernosal ischemia (CCI, n = 5) and control (n = 5) groups, The CCI group underwent balloon endothelial injury of the iliac arteries and received 0.5% cholesterol diet. The control group received a regular diet. After 16 weeks, arteriography was performed then the animals were sacrificed, Theiliac arteries and the entire clitoris were removed. Cross-sections of theiliac arteries and clitoris were processed for histologic evaluation The percentage of smooth muscle and connective tissue in trichrome stained sections of clitoral cavernosal tissue was determined by computer-assisted histomorphometry. Arteriography revealed diffused occlusive disease in the common iliac, internal iliac and pudendal arteries in the CCI group. Histology showed that arterial occlusive disease spreads from the site of balloon injury to the smaller branches involving the clitoral cavernosal arteries. Diffuse fibrosis was observed in the clitoral cross-sections of the CCI group. The percentage of clitoral cavernosal smooth muscle (mean +/- standard error) in the CCI group (53% +/- 0.9%) was significantly decreased compared with the control group (62% +/- 0.8%) (P = 0.0001), Chronic clitoral cavernosal ischemia causes significant fibrosis and loss of smooth muscle in the clitoral cavernosal tissue. These findings suggest that chronic clitoral cavernosal arterial insufficiency may play a role in the pathophysiology of female sexual arousal disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 11:25:00