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Titolo:
Neuron-specific enolase in hemophagocytic lymphohistiocytosis: A potentialindicator for macrophage activation?
Autore:
Honda, K; Ohga, S; Takada, H; Nomura, A; Ohshima, K; Kinukawa, N; Mizuno, Y; Hara, T;
Indirizzi:
Kyushu Univ, Grad Sch Med Sci, Dept Pediat, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 at, Higashi Ku, Fukuoka 8128582, Japan Hamanoumachi Hosp, Div Pediat, Fukuoka, Japan Hamanoumachi Hosp Fukuoka Japan umachi Hosp, Div Pediat, Fukuoka, Japan Fukuoka Univ, Sch Med, Dept Pathol 1, Fukuoka 81401, Japan Fukuoka Univ Fukuoka Japan 81401 ed, Dept Pathol 1, Fukuoka 81401, Japan Kyushu Univ, Grad Sch Med Sci, Dept Med Informat, Fukuoka 812, Japan Kyushu Univ Fukuoka Japan 812 Sci, Dept Med Informat, Fukuoka 812, Japan Fukuoka Municipal Childrens Hosp, Fukuoka, Japan Fukuoka Municipal Childrens Hosp Fukuoka Japan ens Hosp, Fukuoka, Japan Med Ctr Infect Dis, Fukuoka, Japan Med Ctr Infect Dis Fukuoka JapanMed Ctr Infect Dis, Fukuoka, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF HEMATOLOGY
fascicolo: 1, volume: 72, anno: 2000,
pagine: 55 - 60
SICI:
0925-5710(200007)72:1<55:NEIHLA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALIGNANT HISTIOCYTOSIS; INTERFERON-GAMMA; DISEASE-ACTIVITY; SYNDROME HPS; BLOOD-CELLS; CHILDHOOD; CHILDREN; SERUM; MARKER; HYPERCYTOKINEMIA;
Keywords:
hemophagocytic lymphohistiocytosis; neuron-specific enolase; macrophage;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Ohga, S Kyushu Univ, Grad Sch Med Sci, Dept Pediat, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan Kyushu Univ 3-1-1 Maidashi Fukuoka Japan 8128582 a 8128582, Japan
Citazione:
K. Honda et al., "Neuron-specific enolase in hemophagocytic lymphohistiocytosis: A potentialindicator for macrophage activation?", INT J HEMAT, 72(1), 2000, pp. 55-60

Abstract

To determine the pathogenesis of hemophagocytic lymphohistiocytosis (HLH),serum levels of neuron-specific enolase (NSE) and cytokine profiles were investigated. Serum concentrations of NSE and several cytokines were measured by immunoassays, and the association was evaluated in 18 HLH patients. Serum NSE levels increased (>10 ng/mL) in 27/29 samples (93%) during the active febrile phase, the mean level of which (35.9 ng/mL) was much higher thanthat during the remission phase (11.2 ng/mL) (P = .001). The peak levels of NSE in 11 patients who required cytotoxic agents were higher than those in 7 patients without chemotherapy, 64.6 +/- 49.4 and 17.9 +/- 12.9, respectively (P = .265). The NSE levels correlated positively with the levels of interferon (IFN)-gamma (Pearson's correlation coefficient [r] = 0.408, P = .044), soluble interleukin-2 receptor (sIL-2R) (r = 0.464, P = .048), lactate dehydrogenase (r = 0.830, P <.00001), aspartate aminotransferase (r = 0.531, P = .003), acid ferritin (r = 0.715, P = .00001), and correlated negatively with platelet count (r = -0.422, P = .021), but not with other parameters, including tumor necrosis factor-alpha, IL-1 beta, IL-18, soluble Fas ligand and C-reactive protein. Multiple regression analysis indicated that the correlation of NSE with platelet count was independent of other correlations. Sequential NSE changes well reflected the clinical course of patients. Immunohistochemical staining revealed an appreciable number of NSE-positive histiocytes in bone marrow specimens with florid hemophagocytosis. Theseresults suggest that the circulating NSE originated from macrophages stimulated with IFN-gamma/sIL-2R, and partly from the destruction of platelets. Serum NSE level may be a useful marker for predicting the disease progression of HLH. Int J Hematol. 2000;72:55-60. (C) 2000 The Japanese Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 08:50:30