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Titolo:
Familial cancer risks to offspring from mothers with 2 primary breast cancers: Leads to cancer syndromes
Autore:
Hemminki, K; Vaittinen, P; Easton, D;
Indirizzi:
Karolinska Inst, Novum, Dept Biosci, S-14157 Huddinge, Sweden Karolinska Inst Huddinge Sweden S-14157 Biosci, S-14157 Huddinge, Sweden Univ Cambridge, CRC, Genet Epidemiol Unit, Strangeways Res Lab, Cambridge,England Univ Cambridge Cambridge England Strangeways Res Lab, Cambridge,England
Titolo Testata:
INTERNATIONAL JOURNAL OF CANCER
fascicolo: 1, volume: 88, anno: 2000,
pagine: 87 - 91
SICI:
0020-7136(20001001)88:1<87:FCRTOF>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENETIC EPIDEMIOLOGY; TESTICULAR CANCER; DATABASE; PREVALENCE; BRCA1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Hemminki, K Karolinska Inst, Novum, Dept Biosci, S-14157 Huddinge, Sweden Karolinska Inst Huddinge Sweden S-14157 157 Huddinge, Sweden
Citazione:
K. Hemminki et al., "Familial cancer risks to offspring from mothers with 2 primary breast cancers: Leads to cancer syndromes", INT J CANC, 88(1), 2000, pp. 87-91

Abstract

The nationwide Swedish Family-Cancer Database was used to analyse the riskof cancer among the offspring of bilateral breast cancer patients. We studied 4,734 such mothers who had 9,391 offspring, of whom 328 presented with a primary cancer in the years 1958-1996, Standardised incidence ratios (SIRs) were increased for breast [SIR 3.05, 95% confidence interval (CI) 2.57-3.59], ovarian (SIR 1.84, 95% CI 1.03-3.05) and anogenital(SIR 1,75, 95% CI 1.11-2.63) cancers and childhood sarcomas (SIR 9.39, 95% CI 1.9329.13). Additionally, squamous-cell skin cancer was increased among sons and all childhood cancers among daughters. When analysed by histological type, adenocarcinomas of the breast and ovary, all squamous-cell carcinomas and tumours atglandular epithelium (seminomas and intestinal carcinoids) were increased. Mothers with bilateral breast cancer had an excess of 2 or more children with cancer. The increased risk of ovarian cancer is consistent with germline mutations in the BRCA1 and BRCA2 genes, while the risk of soft tissue andbone sarcomas may reflect the association of these tumours with Li-Fraumeni syndrome. The increases in squamous-cell carcinomas at many sites may reflect a new susceptibility syndrome. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 04:39:40