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Titolo:
CD44 isoform expression in synovial sarcoma correlates with epitheliogenesis but not prognosis
Autore:
Sneath, RJ; Mangham, DC;
Indirizzi:
Royal Orthopaed Hosp, Oncol Serv, Birmingham B31 2AP, W Midlands, England Royal Orthopaed Hosp Birmingham W Midlands England B31 2AP lands, England Univ Birmingham, Dept Pathol, Birmingham B15 2TT, W Midlands, England UnivBirmingham Birmingham W Midlands England B15 2TT W Midlands, England
Titolo Testata:
HISTOPATHOLOGY
fascicolo: 2, volume: 37, anno: 2000,
pagine: 166 - 174
SICI:
0309-0167(200008)37:2<166:CIEISS>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOFT-TISSUE SARCOMAS; EPITHELIAL-TYPE DIFFERENTIATION; T-CELL ACTIVATION; SPLICE VARIANTS; GASTRIC-CANCER; MONOCLONAL-ANTIBODY; HYALURONATE BINDING; HIGH ENDOTHELIUM; PRIMARY TUMORS; BREAST-CANCER;
Keywords:
synovial; sarcoma; CD44; immunohistochemical; prognosis; epithelial; differentiation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Mangham, DC Royal Orthopaed Hosp NHS Trust, Dept Musculoskeletal Pathol, 111 Dale Rd, Birmingham, W Midlands, England Royal Orthopaed Hosp NHS Trust 111 Dale Rd Birmingham W Midlands England
Citazione:
R.J. Sneath e D.C. Mangham, "CD44 isoform expression in synovial sarcoma correlates with epitheliogenesis but not prognosis", HISTOPATHOL, 37(2), 2000, pp. 166-174

Abstract

Aims: We immunohistochemically determined the expression of CD44 standard and splice variant isoforms in a series of synovial sarcomas and sought correlations with histological subtype and clinical parameters including outcome,Methods and results: From 39 patients, a total of 56 formalin-fixed and paraffin-embedded tumour samples (including initial, recurrent and metastatictumours) were used to immunohistochemically evaluate the expression of epitopes encoded by CD44s and the CD44 splice variants CD44v3-v10. Significance of proposed prognostic indicators was evaluated in relation to the survival, time to local recurrence and time to metastases using log-rank analysis. Sixty-four percent of synovial sarcomas expressed CD44s and 46% expressedCD44v3-v10 (var), Synovial sarcomas with epithelial or epithelioid areas preferentially expressed CD44s in these areas when compared with the spindlecell element, There were no correlations with clinical parameters or outcome,Conclusions: The expression of CD44 was not found to correlate with survival, local recurrence or metastatic ability. In synovial sarcoma. CD44 and variant isoform expression appears to be associated with the degree of epithelial differentiation. CD44 expression in synovial sarcoma shows interesting similarities to CD44 expression in embryological epitheliogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:13:52