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Titolo:
Organization and conservation of the GART/SON/DONSON locus in mouse and human genomes
Autore:
Wynn, SL; Fisher, RA; Pagel, C; Price, M; Liu, QY; Khan, IM; Zammit, P; Dadrah, K; Mazrani, W; Kessling, A; Lee, JS; Buluwela, L;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, Div Biomed Sci, London W6 8RP, England Univ London Imperial Coll Sci Technol & Med London England W6 8RP ngland Univ London Imperial Coll Sci Technol & Med, Div Neurosci, London W6 8RP, England Univ London Imperial Coll Sci Technol & Med London England W6 8RPngland Hammersmith Hosp, MRC, Clin Res Ctr, London W12 0NN, England Hammersmith Hosp London England W12 0NN Res Ctr, London W12 0NN, England Kennedy Galton Ctr, Acad Unit Med & Community Genet, Harrow HA1 3UJ, Middx, England Kennedy Galton Ctr Harrow Middx England HA1 3UJ w HA1 3UJ, Middx, England St Marks NHS Trust, Harrow HA1 3UJ, Middx, England St Marks NHS Trust Harrow Middx England HA1 3UJ w HA1 3UJ, Middx, England Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA
Titolo Testata:
GENOMICS
fascicolo: 1, volume: 68, anno: 2000,
pagine: 57 - 62
SICI:
0888-7543(20000815)68:1<57:OACOTG>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
RNA SPLICING FACTORS; PROTEIN; DNA; HUMAN-CHROMOSOME-21; CHROMOSOME-21; TRANSLATION; SEQUENCES; CLUSTER; NUCLEUS; FAMILY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Buluwela, L Univ London Imperial Coll Sci Technol & Med, Div Med, Canc Cell Biol Grp, Hammersmith Campus,Du Cane Rd, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med Hammersmith Campus,Du Cane Rd London England W12 0NN
Citazione:
S.L. Wynn et al., "Organization and conservation of the GART/SON/DONSON locus in mouse and human genomes", GENOMICS, 68(1), 2000, pp. 57-62

Abstract

The SON gene, which maps to human chromosome 21q22.1-q22.2, encodes a novel regulatory protein. Here we describe the organization of the Son locus inthe mouse genome. The mouse Son gene spans a region of approximately 35 kb, The coding region is more than 8 kb in length and has been completely sequenced. The gene is organized into 11 coding exons and 1 noncoding 3'UTR exon, with over 70% of the coding region residing in one 5.7-kb exon. The gene contains at least one alternative exon, N/C exon 1, which can be used, bysplicing, to generate a truncated form of the SON protein. Further investigation of the mouse Son locus has identified the genes directly flanking Son. The glycinamide ribonucleotide formyltransferase gene, Gart, is encoded 5' of Son in a head-to-head arrangement, with the start of both genes lyingwithin 899 bp. Sequence comparison with the expressed sequence tagged database identified a novel gene within 65 bp of the 3' end of Son, which we have named Donson. In this unusually compact gene cluster, we have found overlap in the pattern of expression between Gart, Son, and Donson. However, atleast two of these genes have very different functions. While GART is involved in purine biosynthesis, we find that SON shows the characteristics of "SR-type" proteins, which are involved in mRNA processing and gene expression. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 08:11:32