Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Characterization of audiogenic-like seizures in naive rats evoked by activation of AMPA and NMDA receptors in the inferior colliculus
Autore:
Yasuda, S; Ishida, N; Higashiyama, A; Morinobu, S; Kato, N;
Indirizzi:
Shiga Univ Med Sci, Dept Psychiat, Otsu, Shiga 5202192, Japan Shiga Univ Med Sci Otsu Shiga Japan 5202192 t, Otsu, Shiga 5202192, Japan Shiga Univ Med Sci, Hlth Adm Ctr, Otsu, Shiga 5202192, Japan Shiga Univ Med Sci Otsu Shiga Japan 5202192 r, Otsu, Shiga 5202192, Japan Shiga Univ Med Sci, Sch Human Courses, Hikone 5228553, Japan Shiga Univ Med Sci Hikone Japan 5228553 n Courses, Hikone 5228553, Japan Univ Tokyo, Grad Sch Med, Dept Neuropsychiat, Tokyo 1138655, Japan Univ Tokyo Tokyo Japan 1138655 Dept Neuropsychiat, Tokyo 1138655, Japan
Titolo Testata:
EXPERIMENTAL NEUROLOGY
fascicolo: 2, volume: 164, anno: 2000,
pagine: 396 - 406
SICI:
0014-4886(200008)164:2<396:COASIN>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
JORO SPIDER TOXIN; LEARNED AUDITORY RESPONSES; EXCITATORY AMINO-ACIDS; CENTRAL NERVOUS-SYSTEM; FOS MESSENGER-RNA; NEONATAL-HYPOTHYROIDISM; GLUTAMATE RECEPTORS; HIPPOCAMPAL-NEURONS; ANIMAL-MODELS; ADULT-RATS;
Keywords:
audiogenic seizure; NMDA receptors; AMPA receptors; inferior colliculus; cyclothiazide; c-fos; mRNA; propylthiouracil;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Yasuda, S Tokyo Metropolitan Inst Neurosci, Dept Neuropharmacol, 2-6 Musashidai, Tokyo 1838526, Japan Tokyo Metropolitan Inst Neurosci 2-6 MusashidaiTokyo Japan 1838526
Citazione:
S. Yasuda et al., "Characterization of audiogenic-like seizures in naive rats evoked by activation of AMPA and NMDA receptors in the inferior colliculus", EXP NEUROL, 164(2), 2000, pp. 396-406

Abstract

The role of glutamate receptors in the inferior colliculus (IC) in audiogenic and audiogenic-like seizures was investigated in adult rats with transient neonatal hypothyroidism by 0.02% propylthiouracil (PTU) treatment through mother's milk (PTU rats) and in naive rats treated intracisternally withN-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazole-proprionic acid (AMPA), or cyclothiazide, an inhibitor of rapid AMPA receptordesensitization. All rats showed audiogenic or audiogenic-like seizures characterized by running fit (RF) and generalized tonic-clonic seizures (GTCS). While systemically administered MK-801 inhibited GTCS, intracisternally administered NBQX inhibited RF and GTCS in both audiogenic and audiogenic-like seizures. Auditory stimulation shortened the latency to GTCS induced byAMPA, but not NMDA, at a subclinical dose and further elongated the shortened duration of RF, but not GTCS, induced by MK-801 pretreatment. Furthermore, Northern blot analysis was used to evaluate the expression of the immediate-early gene c-fos in the IC following induction of audiogenic or audiogenic-like seizures. The significant induction of c-fos mRNA by audiogenic seizures in PTU rats or by AMPA- or cyclothiazide-induced seizures in naive rats was prominent in the IC. MK-801 suppressed c-fos mRNA expression in the IC induced by audiogenic seizures in PTU rats or by AMPA-induced seizuresin naive rats. NBQX suppressed the expression of c-fos mRNA in the IC induced by AMPA-induced seizures but did not suppress c-fos mRNA in PTU rats orrats with cyclothiazide-induced seizures. Auditory stimuli failed to affect c-fos mRNA induction by AMPA. The present study suggests that audiogenic-like seizures can be reproduced by glutamate receptor agonists in which AMPA receptors are primarily linked to the initiation of audiogenic seizures (RF) while NMDA receptors presumably located within the IC are involved in the propagation of GTCS in audiogenic seizures. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 05:44:27