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Titolo:
Long-lasting regulation of galanin, opioid, and other peptides in dorsal root ganglia and spinal cord during experimental polyarthritis
Autore:
Calza, L; Pozza, M; Arletti, R; Manzini, E; Hokfelt, T;
Indirizzi:
Hesperia Hosp, Pathophysiol Ctr Nervous Syst, I-41100 Modena, Italy Hesperia Hosp Modena Italy I-41100 r Nervous Syst, I-41100 Modena, Italy Univ Bologna, Dept Vet Morphophysiol & Anim Prod, Bologna, Italy Univ Bologna Bologna Italy et Morphophysiol & Anim Prod, Bologna, Italy Univ Modena, Dept Biomed Sci, I-41100 Modena, Italy Univ Modena Modena Italy I-41100 Dept Biomed Sci, I-41100 Modena, Italy Univ Modena, Dept Internal Med, I-41100 Modena, Italy Univ Modena ModenaItaly I-41100 ept Internal Med, I-41100 Modena, Italy Karolinska Inst, Dept Neurosci, Stockholm, Sweden Karolinska Inst Stockholm Sweden Inst, Dept Neurosci, Stockholm, Sweden
Titolo Testata:
EXPERIMENTAL NEUROLOGY
fascicolo: 2, volume: 164, anno: 2000,
pagine: 333 - 343
SICI:
0014-4886(200008)164:2<333:LROGOA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY SENSORY NEURONS; ADJUVANT-INDUCED ARTHRITIS; GENE-RELATED PEPTIDE; POSTHERPETIC NEURALGIA; SUBSTANCE-P; CHRONIC PAIN; NEUROPATHIC PAIN; MESSENGER-RNA; SCIATIC-NERVE; KNEE-JOINT;
Keywords:
galanin; inflammatory pain; neuropathic pain; opioid; polyarthritis; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Calza, L Hesperia Hosp, Pathophysiol Ctr Nervous Syst, Via Arqua 80-A, I-41100 Modena, Italy Hesperia Hosp Via Arqua 80-A Modena Italy I-41100 Modena, Italy
Citazione:
L. Calza et al., "Long-lasting regulation of galanin, opioid, and other peptides in dorsal root ganglia and spinal cord during experimental polyarthritis", EXP NEUROL, 164(2), 2000, pp. 333-343

Abstract

Mechanisms involved in transition from acute to chronic pain are still notwell understood and our means to therapeutically influence this transitionare limited. Moreover, very little is known about longlasting consequencesof prolonged exposure to painful stimuli with regard to phenotypic changesand pain experience. In this study we have analyzed long term behavioral and neurochemical effects of intradermal tail injection of heat-killed mycobacterium butyricum suspended in complete Freund's adjuvant. Calcitonin gene-related peptide (CGRP) and galanin mRNA levels were investigated in dorsalroot ganglia of polyarthritic rats during the acute (21-) and the remission stage (79 days postinjection), and opioid peptide mRNAs and receptors were studied in the spinal cord. Most of the increases in peptide mRNA levels observed during the acute stage of arthritis were still present in the remission stages. Thus, CGRP and galanin mRNAs in DRGs, and opioid peptide mRNAs and opioid receptors in the spinal cord were still strongly up-regulated,when animals do not exhibit spontaneous pain behavior and inflammation. Hot-plate test in the presence of naloxone, performed in the remission stage,indicated that opiates participate in pain threshold regulation after prolonged painful condition. Finally, X-ray examination revealed a complete destruction of joint structure, thus suggesting a parallel lesion of peripheral nerve endings. These results suggest that in the remission stage of chronic joint inflammation several types of mechanisms are activated aiming at counteracting both inflammatory and neuropathic pain. Thus, opioid systems in the dorsal horn as well as galanin in DRG; neurons are upregulated, both alternating pain. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:30:30