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Titolo:
Spatio-temporal distribution of cellular retinoid binding protein gene transcripts in the developing and the adult cochlea. Morphological and functional consequences in CRABP- and CRBPI-null mutant mice
Autore:
Romand, R; Sapin, V; Ghyselinck, NB; Avan, P; Le Calvez, S; Dolle, P; Chambon, P; Mark, M;
Indirizzi:
Univ Blaise Pascal, Neurobiol Lab, F-63177 Aubiere, France Univ Blaise Pascal Aubiere France F-63177 l Lab, F-63177 Aubiere, France Univ Auvergne, Fac Med, F-63001 Clermont Ferrand, France Univ Auvergne Clermont Ferrand France F-63001 1 Clermont Ferrand, France Univ Strasbourg 1, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch, France Univ Strasbourg 1 Illkirch France F-67404 aire, F-67404 Illkirch, France
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 8, volume: 12, anno: 2000,
pagine: 2793 - 2804
SICI:
0953-816X(200008)12:8<2793:SDOCRB>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUDITORY HAIR-CELLS; MOUSE INNER-EAR; ACID RECEPTORS; DIFFERENTIAL PATTERN; MAMMALIAN COCHLEA; NUCLEAR RECEPTORS; NERVOUS-SYSTEM; I EXPRESSION; NEURAL CREST; RAT COCHLEA;
Keywords:
cochlear potentials; in situ hybridization; knockout; ontogenesis; retinoic acid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Romand, R Univ Blaise Pascal, Neurobiol Lab, F-63177 Aubiere, France Univ Blaise Pascal Aubiere France F-63177 3177 Aubiere, France
Citazione:
R. Romand et al., "Spatio-temporal distribution of cellular retinoid binding protein gene transcripts in the developing and the adult cochlea. Morphological and functional consequences in CRABP- and CRBPI-null mutant mice", EUR J NEURO, 12(8), 2000, pp. 2793-2804

Abstract

The expression patterns of the mouse cellular retinoid binding protein genes were investigated by in situ hybridization analysis in the inner ear from 10.5 days post coitum (dpc) up to the adult stage. The cellular retinoic acid binding protein II (CRABPII) and cellular retinol binding protein I (CRBPI) were present in a widespread and abundant pattern in cochlear structures during embryogenesis. Expression of the cellular retinoic acid binding protein I (CRABPI) is restricted during development in Kolliker's organ whilst cellular retinol binding protein II (CRBPII) is only visible after birth with a ubiquitous distribution in most regions of the cochlea including nervous components. No CRABP or CRBP transcripts were observed in the auditory receptors. Morphological observations of CRBPI- and CRABPI/CRABPII-null mutant fetus at 18.5 dpc do not show any structural modification at the level of the organ of Corti. Furthermore, electrophysiological tests performedby measuring distorsion-product otoacoustic emissions and auditory brainstem evoked responses did not present significant alteration of the auditory function for the different types of mutants. The expression of retinoid binding proteins in cochlear structures during embryogenesis could suggest important roles for these proteins during ontogenesis and morphogenesis of theinner ear. Despite these observations, morphological and functional data from mutant mice did not present obvious modifications of the cochlear structures and auditory thresholds. It is therefore unlikely that CRABPs and CRBPI are directly involved in development of the cochlea and hair cell differentiation.

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Documento generato il 30/11/20 alle ore 07:12:18