Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Voltammetry of protonated anesthetics at a liquid membrane: Evaluation of the drug propagation
Autore:
Samec, Z; Trojanek, A; Langmaier, J; Samcova, E; Malek, J;
Indirizzi:
Acad Sci Czech Republ, J Heyrovsky Inst Phys Chem, CZ-18223 Prague 8, Czech Republic Acad Sci Czech Republ Prague Czech Republic 8 3 Prague 8, Czech Republic Charles Univ, Fac Med 3, CZ-10000 Prague, Czech Republic Charles Univ Prague Czech Republic CZ-10000 10000 Prague, Czech Republic
Titolo Testata:
ELECTROANALYSIS
fascicolo: 12, volume: 12, anno: 2000,
pagine: 901 - 904
SICI:
1040-0397(200008)12:12<901:VOPAAA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
OCTYL ETHER INTERFACE; IONIC PARTITION DIAGRAMS; PHARMACOLOGICAL ACTIVITY; POLARIZATION PHENOMENA; TRANSFER KINETICS; WATER; ELECTROLYTES;
Keywords:
ion voltammetry; liquid membrane; local anesthetics; evaluation of drug propagation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Samec, Z Acad Sci Czech Republ, J Heyrovsky Inst Phys Chem, Dolejskova 3, CZ-18223 Prague 8, Czech Republic Acad Sci Czech Republ Dolejskova 3 Prague Czech Republic 8 ublic
Citazione:
Z. Samec et al., "Voltammetry of protonated anesthetics at a liquid membrane: Evaluation of the drug propagation", ELECTROANAL, 12(12), 2000, pp. 901-904

Abstract

Voltammetric measurements are used to study the transfer of protonated forms of local anesthetics (procaine, tetracaine, prilocaine, bupivacaine, lidocaine, dibucaine) across a supported o-nitrophenyl octyl ether (o-NPOE) membrane. Ion diffusion coefficients and ion transfer potentials were obtained which are comparable with those inferred from measurements at a water-o-NPOE interface. It is shown that the pharmacological potency of local anesthetics correlates with standard ion transfer potentials of their protonated forms. It is proposed that the drug propagation involves the transfer of the ionic rather than uncharged anesthetic across the cell membrane.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:51:51