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Titolo:
Prevention of encephalomyocarditis virus-induced diabetes by live recombinant Mycobacterium bovis bacillus Calmette-Guerin in susceptible mice
Autore:
Choi, BK; Cho, SH; Bai, GH; Kim, SJ; Hyun, BH; Choe, YK; Bae, YS;
Indirizzi:
Hannam Univ, Dept Microbiol, Taejon 300791, South Korea Hannam Univ Taejon South Korea 300791 robiol, Taejon 300791, South Korea Korean Inst TB, Dept Bacteriol, Seocho Gu, Seoul, South Korea Korean Inst TB Seoul South Korea cteriol, Seocho Gu, Seoul, South Korea Korea Res Inst Biosci & Biotechnol, Taejon, South Korea Korea Res Inst Biosci & Biotechnol Taejon South Korea ejon, South Korea
Titolo Testata:
DIABETES
fascicolo: 9, volume: 49, anno: 2000,
pagine: 1459 - 1467
SICI:
0012-1797(200009)49:9<1459:POEVDB>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTATHIONE-S-TRANSFERASE; T-LYMPHOCYTE RESPONSES; PANCREATIC BETA-CELLS; SURFACE PROTEIN-A; IMMUNE-RESPONSES; NONDIABETOGENIC VARIANTS; MOLECULAR MIMICRY; DENDRITIC CELLS; COXSACKIE-VIRUS; CAPSID PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Bae, YS Hannam Univ, Dept Microbiol, Ojeong Dong 133, Taejon 300791, SouthKorea Hannam Univ Ojeong Dong 133 Taejon South Korea 300791 South Korea
Citazione:
B.K. Choi et al., "Prevention of encephalomyocarditis virus-induced diabetes by live recombinant Mycobacterium bovis bacillus Calmette-Guerin in susceptible mice", DIABETES, 49(9), 2000, pp. 1459-1467

Abstract

The D variant of encephalomyocarditis (EMC-D) virus causes diabetes in susceptible mice by direct cytolysis of pancreatic beta-cells. cDNA covering the major outer capsid protein (VP1) of the EMC-D virus was cloned into Mycobacterium bovis bacillus Calmette-Guerin (BCG), None of the SJL/J mice immunized with live recombinant BCG-VP1 (rBCG-VP1) became diabetic when challenged with the highly diabetogenic EMC-D virus, but the control mice inoculated with normal BCG developed diabetes during the same challenge. VP1-specific antibodies (including neutralizing antibodies) were markedly increased over time and reached the maximum titer at week 10 after a single immunization. The plateau of the titer lasted longer than 4 weeks. Mice and guinea pigs immunized with live rBCG-VP1 showed strong delayed-type hypersensitivityto the VP1 of the EMC-D virus, The preventive immunity still worked effectively 10 months after the primary immunization. At that; time, the VP1-specific antibody was almost undetectable in the bloodstream, but a large number of VP1-specific lymphocytes was found in the spleen of the immunized mice, Our results show that live rBCG-VP1 elicits effective humoral and long-lasting cellular immune responses against EMC-D virus infection that results in the prevention of virus-induced diabetes in susceptible mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 02:10:31