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Titolo:
A molecular basis for estrogen-induced cryptorchidism
Autore:
Nef, S; Shipman, T; Parada, LF;
Indirizzi:
Univ Texas, SW Med Ctr, Ctr Dev Biol, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 ed Ctr, Ctr Dev Biol, Dallas, TX 75390 USA
Titolo Testata:
DEVELOPMENTAL BIOLOGY
fascicolo: 2, volume: 224, anno: 2000,
pagine: 354 - 361
SICI:
0012-1606(20000815)224:2<354:AMBFEC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
STEROIDOGENIC FACTOR-I; TESTICULAR DESCENT; GUBERNACULAR DEVELOPMENT; HORMONAL-CONTROL; LEYDIG-CELLS; FETAL TESTIS; MICE; RAT; EXPRESSION; DIETHYLSTILBESTROL;
Keywords:
Insl3; RLF; Ley I-L; cryptorchidism; estradiol; Estriol; DES; gubernaculum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Parada, LF Univ Texas, SW Med Ctr, Ctr Dev Biol, 6000 Harry Hines Blvd, Dallas, TX 75390 USA Univ Texas 6000 Harry Hines Blvd Dallas TX USA 75390 75390 USA
Citazione:
S. Nef et al., "A molecular basis for estrogen-induced cryptorchidism", DEVELOP BIO, 224(2), 2000, pp. 354-361

Abstract

Male sexual differentiation relies upon testicular secretion of the hormones testosterone, Mullerian inhibiting substance, and insulin-3 (Insl3). Insl3 is responsible for testicular descent through virilization and outgrowthof the embryonic gubernaculum. In mouse, prenatal exposure to 17 beta-estradiol and the nonsteroidal synthetic estrogen diethylstilbestrol (DES) disturbs the endocrine balance, causing demasculinizing and feminizing effects in the male embryo, including impaired testicular descent (cryptorchidism). In the current study, we show that maternal exposure to estrogens, including 17 alpha- and beta-estradiol, as well as DES, specifically down regulates Insl3 expression in embryonic Leydig cells, thereby providing a mechanismfor cryptorchidism. These experiments may have implications for the widespread use of estrogenic substances in agriculture and the environment. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 13:59:48