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Titolo:
Chemokines as therapeutic targets in renal disease
Autore:
Holdsworth, SR; Kitching, AR; Tipping, PG;
Indirizzi:
Monash Univ, Monash Med Ctr, Dept Med, Clayton, Vic 3168, Australia MonashUniv Clayton Vic Australia 3168 Med, Clayton, Vic 3168, Australia
Titolo Testata:
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
fascicolo: 5, volume: 9, anno: 2000,
pagine: 505 - 511
SICI:
1062-4821(200009)9:5<505:CATTIR>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCYTE CHEMOATTRACTANT PROTEIN-1; EXPERIMENTAL GLOMERULONEPHRITIS; CRESCENTIC GLOMERULONEPHRITIS; RECEPTOR EXPRESSION; GLOMERULAR INJURY; MESANGIAL CELLS; DUFFY ANTIGEN; RECRUITMENT; RESPONSES; NEPHRITIS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Holdsworth, SR Monash Univ, Monash Med Ctr, Dept Med, 246 clayton Rd, Clayton, Vic 3168, Australia Monash Univ 246 clayton Rd Clayton Vic Australia 3168 ralia
Citazione:
S.R. Holdsworth et al., "Chemokines as therapeutic targets in renal disease", CURR OP NEP, 9(5), 2000, pp. 505-511

Abstract

Increased understanding of the fundamental importance of the role of chemokines and their receptors in inflammation, together with the demonstration of their involvement in human and experimental inflammatory renal disease, make these molecules potential therapeutic targets. A number of recent studies using genetically deficient mice and chemokine receptor antagonists in animal models have demonstrated that chemokine inhibition can attenuate experimental renal injury. Because there is simultaneous expression of multiple chemokines and receptors in disease, strategies that are aimed at antagonizing multiple chemokines receptor interactions are likely to be more effective than therapies that target a single chemokine. It is also now recognized that chemokines are involved in normal immune development and immune regulation. These observations, together with the results of studies that havedemonstrated deleterious effects of chemokine receptor antagonism in experimental renal disease, highlight the need for thorough understanding of therole of individual chemokines in the pathogenesis of different types of renal disease before optimal therapeutic interventions may be achieved. Curr Opin Nephrol Hypertens 9:505-511. (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 09:54:11