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Titolo:
Autoimmune-prone mice share a promoter haplotype associated with reduced expression and function of the Fc receptor Fc gamma RII
Autore:
Pritchard, NR; Cutler, AJ; Uribe, S; Chadban, SJ; Morley, BJ; Smith, KGC;
Indirizzi:
Univ Cambridge, Sch Clin Med, Cambridge Inst Med Res, Addenbrookes Hosp, Cambridge CB2 2XY, England Univ Cambridge Cambridge England CB2 2XY osp, Cambridge CB2 2XY, England Univ Cambridge, Sch Clin Med, Dept Med, Addenbrookes Hosp, Cambridge CB2 2XY, England Univ Cambridge Cambridge England CB2 2XY osp, Cambridge CB2 2XY, England Univ London Imperial Coll Sci Technol & Med, Sch Med, Rheumatol Sect, Div Med, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med London England W12 0NN gland
Titolo Testata:
CURRENT BIOLOGY
fascicolo: 4, volume: 10, anno: 2000,
pagine: 227 - 230
SICI:
0960-9822(20000224)10:4<227:AMSAPH>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONOBESE DIABETIC MICE; SYSTEMIC LUPUS-ERYTHEMATOSUS; NOD MICE; SUSCEPTIBILITY; CHROMOSOME-1; MACROPHAGES; NEPHRITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Smith, KGC Univ Cambridge, Sch Clin Med, Cambridge Inst Med Res, Addenbrookes Hosp, Box 139, Cambridge CB2 2XY, England Univ Cambridge Box 139 Cambridge England CB2 2XY 2XY, England
Citazione:
N.R. Pritchard et al., "Autoimmune-prone mice share a promoter haplotype associated with reduced expression and function of the Fc receptor Fc gamma RII", CURR BIOL, 10(4), 2000, pp. 227-230

Abstract

Human autoimmune diseases thought to arise from the combined effects of multiple susceptibility genes include systemic lupus erythematosus (SLE) and autoimmune diabetes. Well-characterised polygenic mouse models closely resembling each of these diseases exist, and genetic evidence links receptors for the Fc portion of immunoglobulin G (FcR) with their pathogenesis in miceand humans [1-3]. FcRs may be activatory or inhibitory and regulate a variety of Immune and inflammatory processes [4,5]. Fc gamma RII (CD32) negatively regulates activation of cells including B cells and macrophages [6]. Fcgamma RII-deficient mice are prone to immune mediated disease [7-9]. The gene encoding Fc gamma RII, Fcgr2, is contained in genetic susceptibility Intervals in mouse models of SLE such as the New Zealand Black (NZB) contribution to the (NZB x New Zealand White (NZW)) F1 strain [1,10,11] and the BXSB strain [12], and in human SLE [1-3]. We therefore sequenced Fcgr2 and identified a haplotype defined by deletions in the Fcgr2 promoter region that is present in major SLE-prone mouse strains (NZB, BXSB, SB/Le, MRL, 129 [13]) and non-obese diabetic (NOD) mice but absent in control strains (BALB/c,C57BL/6, DBA/2, C57BL/10) and NZW mice. The autoimmune haplotype was associated with reduced cell-surface expression of Fc gamma RII on macrophages and activated B cells and with hyperactive macrophages resembling those of Fc gamma RII-deficient mice, and is therefore likely to play an important role in the pathogenesis of SLE and possibly diabetes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 03:07:23