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Titolo:
Endogenous glucocorticoids and antigen-induced acute and late phase pulmonary responses
Autore:
Peebles, RS; Togias, A; Bickel, CA; Diemer, FB; Hubbard, WC; Schleimer, RP;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Med, Div Clin Immunol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 mmunol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Med, Div Resp & Crit Care Med, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 re Med, Baltimore, MD 21205 USA
Titolo Testata:
CLINICAL AND EXPERIMENTAL ALLERGY
fascicolo: 9, volume: 30, anno: 2000,
pagine: 1257 - 1265
SICI:
0954-7894(200009)30:9<1257:EGAAAA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATE ASTHMATIC RESPONSE; HORMONAL RESPONSES; SURGICAL STRESS; INHALATION; CORTISOL; RELEASE; CELLS; INHIBITION; CHALLENGE;
Keywords:
asthma; glucocorticoids; allergen challenge; late phase response; bronchospasm;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Schleimer, RP Johns Hopkins Asthma & Allergy Ctr, 5501 Hopkins Bayview Circle, Baltimore, MD 21224 USA Johns Hopkins Asthma & Allergy Ctr 5501 Hopkins Bayview Circle Baltimore MD USA 21224
Citazione:
R.S. Peebles et al., "Endogenous glucocorticoids and antigen-induced acute and late phase pulmonary responses", CLIN EXP AL, 30(9), 2000, pp. 1257-1265

Abstract

Background Several studies suggest that endogenous glucocorticoids can dampen the severity of experimental allergic reactions in animals. Objective To investigate the influence that endogenous glucocorticoids have on the course of IgE-mediated pulmonary early and late phase reactions. Methods Twenty-one allergic asthmatic and six healthy control subjects underwent inhaled antigen challenge with measurements of plasma cortisol and cortisone by gas chromatography-mass spectrometry. Results There were no differences between the asthmatic and control groupsin the baseline levels of cortisol or cortisone. However, the asthmatic subjects had significantly higher cortisol levels (67.2 +/- 8.6 vs 35.1 +/- 4.5 ng/mL; P = 0.04) and had higher cortisol/ cortisone ratios (4.8 +/- 0.6 vs 3.0 +/- 0.2; P = 0.01) sh after challenge compared to the control subjects. Among the asthmatic subjects, those whose FEV1 recovered rapidly had higher baseline levels of cortisol and those who displayed a late phase reaction had lower levels of cortisol during the late phase period. Conclusion The results suggest that endogenous glucocorticoids may play a significant role in the modulation of airway responses to antigen challenge, and that antigen challenge may induce cortisol production in allergic subjects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 11:17:11