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Titolo:
Effects of once daily dosing with inhaled budesonide on airway hyperresponsiveness and airway inflammation following repeated low-dose allergen challenge in atopic asthmatics
Autore:
Gauvreau, GM; Sulakvelidze, I; Watson, RM; Inman, MD; Rerecich, TJ; OByrne, PM;
Indirizzi:
St Josephs Hosp, Asthma Res Grp, Hamilton, ON L8N 4A6, Canada St Josephs Hosp Hamilton ON Canada L8N 4A6 , Hamilton, ON L8N 4A6, Canada McMaster Univ, Dept Med, Hamilton, ON, Canada McMaster Univ Hamilton ON Canada er Univ, Dept Med, Hamilton, ON, Canada
Titolo Testata:
CLINICAL AND EXPERIMENTAL ALLERGY
fascicolo: 9, volume: 30, anno: 2000,
pagine: 1235 - 1243
SICI:
0954-7894(200009)30:9<1235:EOODDW>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR BASIC-PROTEIN; INDUCED SPUTUM; BRONCHIAL RESPONSIVENESS; GRASS-POLLEN; PREDNISONE; RESPONSES; EXPOSURE; INCREASE; CELLS; EPITHELIUM;
Keywords:
low-dose allergen challenge; glucocorticosteroid; airway hyperresponsiveness; airway inflammation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: O'Byrne, PM St Josephs Hosp, Firestone Chest & Allergy Unit, Room R113,50 Charlton AveE, Hamilton, ON L8N 4A6, Canada St Josephs Hosp Room R113,50 Charlton Ave E Hamilton ON Canada L8N 4A6
Citazione:
G.M. Gauvreau et al., "Effects of once daily dosing with inhaled budesonide on airway hyperresponsiveness and airway inflammation following repeated low-dose allergen challenge in atopic asthmatics", CLIN EXP AL, 30(9), 2000, pp. 1235-1243

Abstract

Background Repeated low-dose allergen challenge increases airway hyperresponsiveness and sputum eosinophils in atopic asthmatics. Inhaled corticosteroids attenuate the airway responses to high-dose allergen challenge, but have not been evaluated against repeated low dose challenge. Objective This study evaluates the effects of once daily treatments of twodoses of inhaled budesonide on airway responses to repeated low-dose allergen challenge. Methods Eight atopic asthmatics with a dual airway responses to inhaled allergen were recruited into a randomized, double-blind crossover, placebo-controlled study. In the mornings of four consecutive days (day 1-day 4), subjects inhaled budesonide 100 mu g, 400 mu g, or placebo, 30 min before inhaling a concentration of allergen causing a 5% early fall in FEV1. Airway hyperresponsiveness to methacholine and sputum eosinophils were measured at baseline, on the afternoon of day 2, day 4, and 24 h after the last challenge. There was a 1-week washout between each of the three treatment periods. Results The repeated low-dose allergen challenge induced increases in the percentage sputum eosinophils from 2.0 +/- 0.7% at baseline to 16.6 +/- 7.1% on day 4 (P = 0.002), and this effect was reduced by once daily budesonide 100 mu g to 5.6 +/- 1.8% (P = 0.01) and by once daily budesonide 400 mu gto 3.1 +/- 0.9% (P=0.004). Also, the allergen-induced methacholine airway hyperresponsiveness which occurred by day 4 (P=0.03) of the repeated low dose challenge was inhibited by budesonide 400 mu g (P = 0.017). Conclusion Both budesonide 100 mu g and 400 mu g inhaled once daily significantly reduces allergen-induced sputum eosinophilia after repeated low dose challenge; however, only the higher dose also attenuates the allergen-induced airway hyperresponsiveness.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/02/20 alle ore 14:19:05