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Titolo:
Postexercise ischemia is associated with increased neuropeptide Y in patients with coronary artery disease
Autore:
Gullestad, L; Jorgensen, B; Bjuro, T; Pernow, J; Lundberg, JM; Dota, CD; Hall, C; Simonsen, S; Ablad, B;
Indirizzi:
AstraZeneca, Molndal, Sweden AstraZeneca Molndal SwedenAstraZeneca, Molndal, Sweden Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden Karolinska Inst Stockholm Sweden Physiol & Pharmacol, Stockholm, Sweden Karolinska Hosp, Dept Cardiol, S-10401 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-10401 diol, S-10401 Stockholm, Sweden Wallenberg Lab, Gothenburg, Sweden Wallenberg Lab Gothenburg SwedenWallenberg Lab, Gothenburg, Sweden Univ Hosp, Rikshosp, Dept Cardiol, Oslo, Norway Univ Hosp Oslo NorwayUniv Hosp, Rikshosp, Dept Cardiol, Oslo, Norway Univ Hosp, Rikshosp, Inst Internal Med, Oslo, Norway Univ Hosp Oslo Norway v Hosp, Rikshosp, Inst Internal Med, Oslo, Norway
Titolo Testata:
CIRCULATION
fascicolo: 9, volume: 102, anno: 2000,
pagine: 987 - 993
SICI:
0009-7322(20000829)102:9<987:PIIAWI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ST-SEGMENT DEPRESSION; RECOVERY-PHASE PATTERNS; SYMPATHETIC ACTIVATION; ANGINA-PECTORIS; EXERCISE; PLASMA; HEART; CATECHOLAMINES; VASOCONSTRICTION; IMMUNOREACTIVITY;
Keywords:
coronary disease; exercise; ischemia; peptides;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Gullestad, L Baerum Hosp, Dept Med, N-1306 Baerum Postterminal, Norway Baerum Hosp Baerum Postterminal Norway N-1306 minal, Norway
Citazione:
L. Gullestad et al., "Postexercise ischemia is associated with increased neuropeptide Y in patients with coronary artery disease", CIRCULATION, 102(9), 2000, pp. 987-993

Abstract

Background-Neurohormones may influence Vascular tone both during and afterexercise. Neuropeptide Y (NPY), which is costored and released with norepinephrine (NE) during sympathetic activity, is a potent vasoconstrictor witha relatively long half-life. We therefore examined its possible association with the ischemic response to exercise in patients with coronary artery disease. Methods and Results-Twenty-nine male patients with effort-induced angina pectoris underwent a symptom-limited exercise test. In addition to conventional ST-segment analysis, we examined ischemia on the basis of heart rate (HR)-adjusted ST-segment changes through calculation of the ST/HR slope during the final 4 minutes of exercise and of the ST/HR recovery loop after exercise, Blood samples were taken before, during, and after exercise for an analysis of several neurohormones. Mean ST-segment depression was -223+/-20.2mu V (P<0.0001) just before the termination of exercise, followed by a gradual normalization, but it remained significant after 10 minutes (-49+/-8.9mu V, P<0.0001). At the end of exercise, the ST/HR slope, which reflects myocardial ischemia, was -6.0+/-0.77 mu V/HR. In most patients, ST-segment levels at a given HR were lower during recovery than during exercise, here referred to as ST "deficit. " Exercise increased the plasma levels of NPY, NE, epinephrine, and N-terminal proatrial natriuretic peptide, but big endothelin remained unchanged. Although NE and epinephrine peaked at maximal exercise, the highest levels of NPY and N-terminal proatrial natriuretic peptide were observed 4 minutes after exercise. The maximal increase in the NPY correlated significantly with ST-segment depression at 3 minutes after exercise (r= -0.61, P=0.0005), the ST deficit at the corresponding time point (r= - 0.66, P=0.0001), and the duration of ST-segment depression after exercise (r=0.42, P=0.02). In contrast, no such correlations were found for NE. Conclusions-The present study has for the first time demonstrated a correlation between plasma NPY levels and the degree and duration of ST-segment depression after exercise in patients with coronary artery disease, which suggests that NPY may contribute to myocardial ischemia in these patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 09:10:35