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Titolo:
A study of desmoglein 1 autoantibodies in pemphigus vulgaris: racial differences in frequency and the association with a more severe phenotype
Autore:
Harman, KE; Gratian, MJ; Bhogal, BS; Challacombe, SJ; Black, MM;
Indirizzi:
Univ London Kings Coll, Guys Kings & St Thomas Med & Dent Sch, St Thomas Hosp, St Johns Inst Dermatol, London WC2R 2LS, England Univ London Kings Coll London England WC2R 2LS London WC2R 2LS, England Univ London Kings Coll, Guys Kings & St Thomas Med & Dent Sch, Guys Hosp, Dept Oral Med & Pathol, London WC2R 2LS, England Univ London Kings Coll London England WC2R 2LS London WC2R 2LS, England
Titolo Testata:
BRITISH JOURNAL OF DERMATOLOGY
fascicolo: 2, volume: 143, anno: 2000,
pagine: 343 - 348
SICI:
0007-0963(200008)143:2<343:ASOD1A>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRACELLULAR DOMAIN; ITALIAN PATIENTS; FOLIACEUS; ANTIGEN; SUSCEPTIBILITY; BACULOVIRUS; DISEASE; EPITOPE; ALLELES; LESIONS;
Keywords:
clinical phenotype; desmoglein 1; desmoglein 3; enzyme-linked immunosorbent assay; genetic factors; pemphigus vulgaris;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Harman, KE Univ London Kings Coll Hosp, Dept Dermatol, Denmark Hill, London SE5 9RS, England Univ London Kings Coll Hosp Denmark Hill London EnglandSE5 9RS
Citazione:
K.E. Harman et al., "A study of desmoglein 1 autoantibodies in pemphigus vulgaris: racial differences in frequency and the association with a more severe phenotype", BR J DERM, 143(2), 2000, pp. 343-348

Abstract

Background Pemphigus vulgaris (PV) is characterized by pathogenic autoantibodies to desmoglein (Dsg) 3, but additional antibodies to Dsg1, the pemphigus foliaceus antigen, are detectable in some cases. Objectives To investigate the clinical significance of the presence of both Dsg 1 and 3 antibodies. Methods In 79 subjects with PV, enzyme-linked immunosorbent assays were used to detect IgG autoantibodies reactive with the ectodomain of Dsg1 and Dsg3. Results There was a clear association between the clinical phenotype and the Dsg antibody profile, All subjects had Dsg3 autoantibodies and 61% had coexisting Dsg1 antibodies (Dsg3+/Dsg1+). PV limited entirely to the mucosalsurfaces was seen only in Dsg3+/Dsg1- patients, while additional Dsg1 antibodies (Dsg3+/Dsg1+) predicted cutaneous in addition to mucosal involvement. Although minor cutaneous involvement was observed in most Dsg3+/Dsg1- patients, severe cutaneous involvement was seen only in Dsg3+/Dsg1+ patients. Dsg1 antibodies were detectable early in the course of disease and their appearance did not relate to the use of systemic therapy, The proportion of Dsg1+ patients was higher in those of Indian origin compared with white northern Europeans (P < 0.05). Conclusions These data suggest that the presence of Dsg1 antibodies is predictive of a potentially more severe disease and that genetic factors may determine the Dsg antibody profile.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 22:50:18