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Titolo:
An fMRI study of sex differences in regional activation to a verbal and a spatial task
Autore:
Gur, RC; Alsop, D; Glahn, D; Petty, R; Swanson, CL; Maldjian, JA; Turetsky, BI; Detre, JA; Gee, J; Gur, RE;
Indirizzi:
Univ Penn, Med Ctr, Brain Behav Lab, Neuropsychiat Sect,Dept Psychiat, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Psychiat, Philadelphia, PA 19104 USA Univ Penn, Dept Radiol, MRI Sect, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 MRI Sect, Philadelphia, PA 19104 USA Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA Univ Penn PhiladelphiaPA USA 19104 pt Neurol, Philadelphia, PA 19104 USA
Titolo Testata:
BRAIN AND LANGUAGE
fascicolo: 2, volume: 74, anno: 2000,
pagine: 157 - 170
SICI:
0093-934X(200009)74:2<157:AFSOSD>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; PLANUM-TEMPORALE; COGNITIVE ACTIVITY; PERFORMANCE; ASYMMETRY; BRAIN; SCHIZOPHRENIA; HANDEDNESS; INCREASES; REVERSAL;
Keywords:
sex differences; men; women; fMRI; cognition; lateralization; spatial; verbal reasoning; left hemisphere; right hemisphere; inferior parietal lobe; planum temporale;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Gur, RC Univ Penn, Med Ctr, Brain Behav Lab, Neuropsychiat Sect,Dept Psychiat, 10th Floor Gates Blvd, Philadelphia, PA 19104 USA Univ Penn 10th FloorGates Blvd Philadelphia PA USA 19104 9104 USA
Citazione:
R.C. Gur et al., "An fMRI study of sex differences in regional activation to a verbal and a spatial task", BRAIN LANG, 74(2), 2000, pp. 157-170

Abstract

Sex differences in cognitive performance have been documented, women performing better on some phonological tasks and men on spatial tasks. An earlier fMRI study suggested sex differences in distributed brain activation during phonological processing, with bilateral activation seen in women while men showed primarily left-lateralized activation. This blood oxygen level-dependent fMRI study examined sex differences (14 men, 13 women) in activation for a spatial task (judgment of line orientation) compared to a verbal-reasoning task (analogies) that does not typically show sex differences. Taskdifficulty was manipulated. Hypothesized ROI-based analysis documented theexpected left-lateralized changes for the verbal task in the inferior parietal and planum temporale regions in both men and women, but only men showed right-lateralized increase for the spatial task in these regions. Image-based analysis revealed a distributed network of cortical regions activated by the tasks, which consisted of the lateral frontal, medial frontal, mid-temporal, occipitoparietal, and occipital regions. The activation was more left lateralized for the verbal and more right for the spatial tasks, but men also showed some left activation for the spatial task, which was nor seenin women. Increased task difficulty produced more distributed activation for the verbal and more circumscribed activation for the spatial task. The results suggest that failure to activate the appropriate hemisphere in regions directly involved in task performance may explain certain sex differences in performance. They also extend, for a spatial task, the principle that bilateral activation in a distributed cognitive system underlies sex differences in performance. (C) 2000 Academic Press.

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Documento generato il 18/01/20 alle ore 01:54:23