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Titolo:
Identification of quantitative trait loci influencing alcohol consumption in the high alcohol drinking and low alcohol drinkingt rat lines
Autore:
Foroud, T; Bice, P; Castelluccio, P; Bo, RH; Miller, L; Ritchotte, A; Lumeng, L; Li, TK; Carr, LG;
Indirizzi:
Indiana Univ, Sch Med, Dept Mol & Med Genet, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 Genet, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Med, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 pt Med, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN 46202 USAIndiana Univ Indianapolis IN USA 46202 l Biol, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Pharmacol, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 rmacol, Indianapolis, IN 46202 USA
Titolo Testata:
BEHAVIOR GENETICS
fascicolo: 2, volume: 30, anno: 2000,
pagine: 131 - 140
SICI:
0001-8244(200003)30:2<131:IOQTLI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN TRANSPORTER GENE; FAMILY-BASED ANALYSIS; ETHANOL-CONSUMPTION; NUCLEUS-ACCUMBENS; INBRED STRAINS; PREFERENCE; MICE; ASSOCIATION; DEPENDENCE; DOPAMINE;
Keywords:
quantitative trait locus (QTL); alcoholism; noninbred rat lines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Foroud, T Indiana Univ, Sch Med, Dept Mol & Med Genet, 975 W Walnut St,IB-155, Indianapolis, IN 46202 USA Indiana Univ 975 W Walnut St,IB-155 Indianapolis IN USA 46202 SA
Citazione:
T. Foroud et al., "Identification of quantitative trait loci influencing alcohol consumption in the high alcohol drinking and low alcohol drinkingt rat lines", BEHAV GENET, 30(2), 2000, pp. 131-140

Abstract

Selective breeding has been employed to develop high-alcohol-drinking (HAD) and low-alcohol-drinking (LAD) rat lines from the heterogeneous N/Nih rat. Within-family selection and a rotational breeding design were used to discourage inbreeding (Li rr al, 1993). To identify quantitative trait loci (QTLs) contributing to alcohol consumption, reciprocal HAD and LAD matings inconjunction with Fl intercrosses were used to create 459 F2 progeny. Usingselective genotyping of 151 FZ progeny with extreme alcohol consumption scores and a novel least squares method developed by Haley et al (1994), fivechromosomal regions (1,5,10,12, and 16) were identified with lod scores greater than 2.0. Genotyping of the entire sample of 459 F2 progeny produced maximum lod scores of 3.5 on chromosome 5, 2.4 on chromosome 10, 4.7 on chromosome 12 and 2.9 on chromosome 16. The evidence of linkage to chromosome I diminished substantially to a maximum lod score of 0.5 when all F2 progeny were genotyped. This study is the first genome-wide study for QTLs underlying alcohol consumption that has employed noninbred lines. Further localization of these QTLs will likely provide insight and candidate genes for thestudy of human alcoholism.

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Documento generato il 01/04/20 alle ore 18:08:29