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Titolo:
Garlic exerts hepatoprotective effects during 4-nitroquinoline 1-oxide-induced oral carcinogenesis in rats
Autore:
Balasenthil, S; Nagini, S;
Indirizzi:
Annamalai Univ, Fac Sci, Dept Biochem, Annamalainagar 608002, Tamil Nadu, India Annamalai Univ Annamalainagar Tamil Nadu India 608002 , Tamil Nadu, India
Titolo Testata:
ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION
fascicolo: 2, volume: 9, anno: 2000,
pagine: 136 - 138
SICI:
0964-7058(2000)9:2<136:GEHED4>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
BUCCAL POUCH CARCINOGENESIS; GASTRIC CARCINOGENESIS; LIPID PEROXIDES; PLANT-PRODUCTS; GLUTATHIONE; NEEM; 7,12-DIMETHYLBENZANTHRACENE; EXTRACT; LIVER; MICE;
Keywords:
antioxidants; chemoprevention; garlic; glutathione; lipid peroxidation; liver; 4-nitroquinoline 1-oxide; oral cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Nagini, S Annamalai Univ, Fac Sci, Dept Biochem, Annamalainagar 608002, Tamil Nadu, India Annamalai Univ Annamalainagar Tamil Nadu India 608002 du, India
Citazione:
S. Balasenthil e S. Nagini, "Garlic exerts hepatoprotective effects during 4-nitroquinoline 1-oxide-induced oral carcinogenesis in rats", ASIA P J CL, 9(2), 2000, pp. 136-138

Abstract

The modifying effects of garlic (Allium sativum Linn.) on hepatic lipid peroxidation and antioxidant status during 4-nitroquinoline 1-oxide ( 4NQO)-induced oral carcinogenesis were investigated in male Wistar rats. Enhanced lipid peroxidation in the liver of tumour-bearing animals was accompanied by significant decreases in the activities of glutathione peroxidase (GPx), glutathione 8-transferase (GST) and reduced glutathione (GSH) levels. Administration of aqueous garlic extract significantly lowered lipid peroxidation and enhanced the levels of hepatic antioxidants and detoxifying enzymes. The results of the present study suggest that garlic exerts its hepatoprotective effects by influencing hepatic biotransformation enzymes and antioxidants.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 14:27:34