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Titolo:
SYNTHESIS AND PROPERTIES OF 2-CARBOXYALKYL-1,2-BENZISOSELENAZOL-3(2H)-ONES AND RELATED ORGANOSELENIUM COMPOUNDS AS NITRIC-OXIDE SYNTHASE INHIBITORS AND CYTOKINE INDUCERS
Autore:
MLOCHOWSKI J; GRYGLEWSKI RJ; INGLOT AD; JAKUBOWSKI A; JUCHNIEWICZ L; KLOC K;
Indirizzi:
WROCLAW TECH UNIV,INST ORGAN CHEM BIOCHEM & BIOTECHNOL,WYB WYSPIANSKIEGO 27 PL-50370 WROCLAW POLAND JAGIELLONIAN UNIV,COLL MED,DEPT PHARMACOL PL-31531 KRAKOW POLAND POLISH ACAD SCI,INST IMMUNOL & EXPT THERAPY PL-53114 WROCLAW POLAND
Titolo Testata:
Liebigs Annalen
fascicolo: 11, , anno: 1996,
pagine: 1751 - 1755
SICI:
0947-3440(1996):11<1751:SAPO2>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL-BLOOD LEUKOCYTES; EBSELEN;
Keywords:
AMINO ACIDS; 1,2-BENZISOSELENAZOL-3(2H)-ONES; CYTOKINE INDUCERS; EBSELEN; NITRIC OXIDE SYNTHASE INHIBITORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
J. Mlochowski et al., "SYNTHESIS AND PROPERTIES OF 2-CARBOXYALKYL-1,2-BENZISOSELENAZOL-3(2H)-ONES AND RELATED ORGANOSELENIUM COMPOUNDS AS NITRIC-OXIDE SYNTHASE INHIBITORS AND CYTOKINE INDUCERS", Liebigs Annalen, (11), 1996, pp. 1751-1755

Abstract

A convenient synthesis of the 2-carboxyalkyl-1,2-benzisoselenazol-3(2H)-ones 4a-k and their esters 41-p from 2-(chloroseleno)benzoyl chloride (2) and amino acids or their carboxy esters is reported. In similarway other 2-substituted 1,2-benzisoselenazol-3(2H)-ones 4q-u were synthesized. The related bis[2-(carbomoyl)phenyl] diselenides 5 were obtained by reductive conversion of 1,2-benzisoselenazol-3(2H)-ones 4 or directly by the reaction of bis[2-(chlorocarbonyl)phenyl] diselenide (3) with compounds having a primary amino group. It was found the some of compounds 4 and 5 are modest cytokine (TNF, IFN) inducers in human peripheral blood leucocyte culture and block the constitutive endothelial nitric oxide synthase (ce NOS).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 01:02:37