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Titolo:
Immunoglobulin isotypes in sera and nasal mucosal secretions and their neonatal transfer and distribution in horses
Autore:
Sheoran, AS; Timoney, JF; Holmes, MA; Karzenski, SS; Crisman, MV;
Indirizzi:
Univ Kentucky, Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USAUniv Kentucky Lexington KY USA 40546 ept Vet Sci, Lexington, KY 40546 USA Univ Cambridge, Dept Clin Vet Med, Cambridge CB3 0ES, England Univ Cambridge Cambridge England CB3 0ES Med, Cambridge CB3 0ES, England Virginia Tech, Virginia Maryland Reg Coll Vet Med, Dept Large Anim Clin Serv, Blacksburg, VA 24061 USA Virginia Tech Blacksburg VA USA 24061 Clin Serv, Blacksburg, VA 24061 USA Univ Maryland, Blacksburg, VA 24061 USA Univ Maryland Blacksburg VA USA 24061 Maryland, Blacksburg, VA 24061 USA
Titolo Testata:
AMERICAN JOURNAL OF VETERINARY RESEARCH
fascicolo: 9, volume: 61, anno: 2000,
pagine: 1099 - 1105
SICI:
0002-9645(200009)61:9<1099:IIISAN>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
STREPTOCOCCUS-EQUI; IGG SUBCLASSES; SECRETORY IGA; C-GAMMA; ANTIBODY; CHAIN; ORGANIZATION; INFECTIONS; RESPONSES; COMPONENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Timoney, JF Univ Kentucky, Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USA Univ Kentucky Lexington KY USA 40546 Lexington, KY 40546 USA
Citazione:
A.S. Sheoran et al., "Immunoglobulin isotypes in sera and nasal mucosal secretions and their neonatal transfer and distribution in horses", AM J VET RE, 61(9), 2000, pp. 1099-1105

Abstract

Objective-To determine concentrations of IgA and IgG subclasses in serum, colostrum, milk, and nasal wash samples of adult horses and foals. Animals-Seven 2-year-old Welsh ponies, 27 adult mixed-breed horses, and 5 Quarter Horse mares and their foals. Procedure-Serum was obtained from ponies and adult horses. Colostrum and milk were obtained from mares and serum and nasal wash samples from their foals immediately after parturition and on days 1, 7, 14, 28, 42, and 63. Nasal wash samples were also obtained from 23 adult horses. Concentrations of immunoglobulins were determined by use of inhibition ELISA. To determine transfer of maternal isotypes to foals, concentrations in colostrum and milk were compared with those in foal serum. Serum half-lives of isotypes in foals were also determined. Results-IgGb was the most abundant isotype in serum and colostrum from adult horses, whereas IgA was the predominant isotype in milk. The major isotype in nasal secretions of adult horses and foals greater than or equal to 28 days old was IgA, but IgGa and IgGb were the major isotypes in nasal secretions of foals less than or equal to 14 days old. Serum half lives of IgGa, IgGb, IgG(T), and IgA in foals were 17.6, 32, 21, and 3.4 days, respectively. Conclusions and Clinical Relevance-The early immunoglobulin repertoire of neonatal foals comprised IgGa, IgG(T), and IgA; endogenous synthesis of IgGb could not be detected until 63 days after birth. The restricted repertoire of immunoglobulins in foals may influence humoral immune responses to vaccination.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 16:44:06