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Titolo:
Cognitive performance is associated with glucose regulation in healthy elderly persons and can be enhanced with glucose and dietary carbohydrates
Autore:
Kaplan, RJ; Greenwood, CE; Winocur, G; Wolever, TMS;
Indirizzi:
Univ Toronto, Fac Med, Dept Nutr Sci, Toronto, ON M5S 3E2, Canada Univ Toronto Toronto ON Canada M5S 3E2 r Sci, Toronto, ON M5S 3E2, Canada Baycrest Ctr Geriatr Care, Kunin Lunenfeld Appl Res Unit, Toronto, ON, Canada Baycrest Ctr Geriatr Care Toronto ON Canada es Unit, Toronto, ON, Canada Baycrest Ctr Geriatr Care, Dept Food & Nutr Serv, Toronto, ON, Canada Baycrest Ctr Geriatr Care Toronto ON Canada tr Serv, Toronto, ON, Canada Baycrest Ctr Geriatr Care, Rotman Res Inst, Toronto, ON, Canada Baycrest Ctr Geriatr Care Toronto ON Canada es Inst, Toronto, ON, Canada Trent Univ, Dept Psychol, Peterborough, ON K9J 7B8, Canada Trent Univ Peterborough ON Canada K9J 7B8 eterborough, ON K9J 7B8, Canada Univ Toronto, Dept Psychol, Toronto, ON M5S 1A1, Canada Univ Toronto Toronto ON Canada M5S 1A1 ychol, Toronto, ON M5S 1A1, Canada Univ Toronto, Dept Psychiat, Toronto, ON M5S 1A1, Canada Univ Toronto Toronto ON Canada M5S 1A1 chiat, Toronto, ON M5S 1A1, Canada St Michaels Hosp, Clin Nutr & Risk Modificat Ctr, Toronto, ON, Canada St Michaels Hosp Toronto ON Canada sk Modificat Ctr, Toronto, ON, Canada St Michaels Hosp, Div Endocrinol & Metab, Toronto, ON, Canada St Michaels Hosp Toronto ON Canada docrinol & Metab, Toronto, ON, Canada
Titolo Testata:
AMERICAN JOURNAL OF CLINICAL NUTRITION
fascicolo: 3, volume: 72, anno: 2000,
pagine: 825 - 836
SICI:
0002-9165(200009)72:3<825:CPIAWG>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-FAT DIETS; ALZHEIMERS-DISEASE; NONDECLARATIVE MEMORY; GLYCEMIC CONTROL; SENILE DEMENTIA; YOUNG-ADULTS; HUMANS; INSULIN; RATS; HYPERINSULINEMIA;
Keywords:
glucose; carbohydrates; insulin; memory; cognition; elderly subjects; beta cells; insulin resistance; glucose regulation; glucose tolerance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Kaplan, RJ Univ Toronto, Fac Med, Dept Nutr Sci, FitzGerald Bldg,150 Coll St, Toronto, ON M5S 3E2, Canada Univ Toronto FitzGerald Bldg,150 Coll St Toronto ON Canada M5S 3E2
Citazione:
R.J. Kaplan et al., "Cognitive performance is associated with glucose regulation in healthy elderly persons and can be enhanced with glucose and dietary carbohydrates", AM J CLIN N, 72(3), 2000, pp. 825-836

Abstract

Background: A glucose drink has been shown to improve memory in persons with poor glucose regulation and poor cognition. Objective: The objective of this study was to determine 1) whether an association between cognition and glucose regulation is apparent in healthy seniors and 2) the effects of dietary carbohydrates on cognition. Design: After an overnight fast, 10 men and 10 women (aged 60-82 y) consumed 50 g carbohydrate as glucose, potatoes, or barley or a placebo on 4 separate mornings, Cognitive tests were administered 15, 60, and 105 min after ingestion of the carbohydrate. Plasma glucose and serum insulin were measured. Results: In a multiple regression analysis, poor baseline (placebo) verbaldeclarative memory (immediate and 20-min delayed paragraph recall and wordlist recall) and visuomotor task performance were predicted by poor beta cell function, high incremental area under the glucose curve, low insulin resistance, and low body mass index. The difference in plasma glucose after food consumption [glucose > potatoes > barley > placebo (P < 0.03)] did not predict performance. Although overall performance did not differ with consumption of the different test foods, baseline score and beta cell function correlated with improvements in immediate and delayed paragraph recall for all 3 carbohydrates (compared with placebo); the poorer the baseline memory or beta cell function, the greater the improvement (correlation between beta cell function and improvement, in delayed paragraph recall: r > -0.50, P < 0.03). Poor beta cell function correlated with improvement for all carbohydrates in visuomotor task performance but not on an attention task. Conclusions: Glucose regulation was associated with cognitive performance in elderly subjects with normal glucose tolerance. Dietary carbohydrates (potatoes and barley) enhanced cognition in subjects with poor memories or beta cell function independently of plasma glucose.

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Documento generato il 15/07/20 alle ore 08:32:46