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Titolo:
Cerebrospinal fluid HIV-1 RNA during treatment with ritonavir/saquinavir or ritonavir/saquinavir/stavudine
Autore:
Gisolf, EH; Enting, RH; Jurriaans, S; de Wolf, F; van der Ende, ME; Hoetelmans, RMW; Portegies, P; Danner, SA;
Indirizzi:
Univ Amsterdam, Acad Med Ctr, Natl AIDS Therapy Evaluat Ctr, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Internal Med, Div Infectious Dis Trop Med & AIDS, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Neurol, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Human Retrovirol, NL-1105 AZ Amsterdam,Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ AZ Amsterdam,Netherlands Acad Hosp, Dept Internal Med, Rotterdam, Netherlands Acad Hosp RotterdamNetherlands pt Internal Med, Rotterdam, Netherlands Slotervaart Hosp, Dept Pharm, Amsterdam, Netherlands Slotervaart Hosp Amsterdam Netherlands pt Pharm, Amsterdam, Netherlands
Titolo Testata:
AIDS
fascicolo: 11, volume: 14, anno: 2000,
pagine: 1583 - 1589
SICI:
0269-9370(20000728)14:11<1583:CFHRDT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; HUMAN PLASMA; ANTIRETROVIRAL THERAPY; ULTRAVIOLET DETECTION; COMBINATION THERAPY; VIRAL LOAD; INFECTION; RITONAVIR; PROTEASE; SAQUINAVIR;
Keywords:
cerebrospinal fluid; HIV-1 RNA; protease inhibitors; stavudine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Danner, SA Univ Amsterdam, Acad Med Ctr, Natl AIDS Therapy Evaluat Ctr, Meibergdreef 9,T0-119, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Meibergdreef 9,T0-119 Amsterdam Netherlands NL-1105 AZ
Citazione:
E.H. Gisolf et al., "Cerebrospinal fluid HIV-1 RNA during treatment with ritonavir/saquinavir or ritonavir/saquinavir/stavudine", AIDS, 14(11), 2000, pp. 1583-1589

Abstract

Objective: To assess the HIV-1-RNA response and drug concentrations in cerebrospinal fluid (CSF) and serum during treatment with saquinavir (SQV)/ritonavir (RTV) or SQV/RTV plus stavudine (d4T) in HIV-1-infected patients. Design: A multicentre, open-label, randomized controlled trial. Methods: A total of 208 protease inhibitor (PI) and d4T-naive, HIV-1-infected patients were treated with RTV 400 mg twice daily and SQV 400 mg twice daily with or without d4T 40 mg twice daily. Intensification with reverse transcriptase inhibitors was allowed if serum HIV RNA remained above 400 copies/ml after 12 weeks. In 27 volunteers, CSF and serum HIV RNA were measured at baseline, weeks 12 and 48, using the Roche Amplicor and the ultrasensitive assay. In 22 patients, serum and CSF drug concentrations were determined at week 12. Results: The median baseline serum and CSF HIV-RNA concentrations were 4.81 and 3.21 log(10) copies/ml, respectively. A difference in the proportion of patients with a CSF: HIV-RNA level below the limit of quantification (< LLQ) after 12 weeks was found: four out of 14 (RTV/SQV) versus 12 out of 13(RTV/SQV/d4T) (P = 0.001). The same results were found using the ultrasensitive assay. Patients with a baseline HIV-RNA level < LLQ in CSF remained <LLQ, regardless of the treatment regimen. Treatment with RTV/SQV alone wasthe only independent predictor of a CSF HTV-RNA level > LLQ at week 12 in logistic regression analysis (P = 0.005). CSF RTV and SQV concentrations were < LLQ in most patients. Conclusion: RTV/SQV alone cannot suppress detectable CSF HIV-1-RNA levels to < LLQ after 12 weeks of treatment in the majority of patients. CSF drug concentrations of RN and SQV < LLQ may explain the suboptimal antiretroviral effect in the CSF. (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:41:57