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Titolo:
Long-term follow-up of patients with AIDS treated with parenteral cidofovir for cytomegalovirus retinitis: the HPMPC Peripheral Cytomegalovirus Retinitis Trial - The Studies of Ocular Complications of AIDS Research Group in collaboration with the AIDS Clinical Trials Group
Autore:
Lewis, RA; Carr, LM; Doyle, K; Fainstein, V; Gross, R; Orengo-Nania, S; Samo, TC; Shigley, JW; Spencer, SS; Weinert, M; Dunn, JP; Bartlett, J; Becker, R; Feinberg, J; Jabs, DA; Johnson, DA; LaSalvia, S; Miller, T; Neisser, LG; Semba, RD; Tay-Kearney, ML; Tucker, P; Barron, B; Jarrott, C; Peyman, G; Swenie, D; Friedman, AH; Ginsburg, R; Sacks, H; Severin, C; Teich, S; Wallach, F; Rescigno, R; Cowan, J; Horan, C; Kloser, P; Wanner, M; Friedberg, DN; Addessi, A; Chachoua, A; Dieterich, D; Hill, J; Hutt, R; Ligh, J; Lorenzo-Latkany, M; Pei, M; Powers, T; Scoppe, C; Weinberg, DV; Jampol, LM; Lyon, AT; Munana, A; Murphy, R; Palella, F; Richine, L; Strugala, Z; Valadez, G; Holland, GN; Carlson, ME; Chafey, S; Hardy, WD; Johiro, AK; MacArthur-Chang, LJ; Martin, MA; Moe, AA; Strong, CA; Tufail, A; Ugalat, PS; Weisz, JM; Freeman, WR; Arevalo-Colina, JF; Clark, T; Jarman, CL; Meixner, L; Meng, TC; Spector, S; Taskintuna, I; Torriani, FJ; ODonnell, J; Alfred, P; Ballesteros, F; Clay, D; Coleman, R; Gordon, K; Gumbley, D; Hoffman, J; Irvine, A; Jacobson, M; Larson, J; Macalalag, L; Narahara, M; Payne, M; Seiff, S; Wilson, S; Woodring, H; Davis, J; Mendez, P; Murray, T; Simmons, T; van der Horst, C; Kylstra, J; Wohl, D; Ziman, K; Pavan, PR; Bergen, GA; Cohen, SM; Craig, JA; Dehler, RL; Elbert, E; Fox, RW; Grizzard, WS; Hammer, ME; Hernandez, LS; Herrera, S; Holt, D; Kemp, S; Larkin, JA; Ledford, DK; Lockey, RF; Menosky, MM; Millard, S; Nadler, JP; Nelson, RP; Norris, D; Ormerod, LD; Pautler, SE; Poblete, SJ; Rodriguez, D; Rosenbach, KP; Seekins, DW; Toney, JR; Jabs, DA; Dodge, JM; Klemstine, JL; Schuerholtz, TA; Stevens, M; Meinert, CL; Amend-Libercci, D; Coleson, L; Collins, KL; Collison, BJ; Dawson, C; Dodge, J; Donithan, M; Ewing, C; Fink, N; Gerczak, C; Harle, J; Holbrook, JT; Huffman, R; Isaacson, MR; Gilpin, AMK; Lane, M; Levine, CR; Martin, B; Meinert, J; Nowakowski, DJ; Owens, RM; Piantadosi, B; Saah, A; Smith, M; Tonascia, J; Van Natta, ML; Davis, MD; Armstrong, J; Brickbauer, J; Brothers, R; Chop, M; Hubbard, L; Hurlburt, D; Kastorff, L; Magli, Y; Neider, M; Onofrey, J; Stoppenbach, V; Vanderhoof-Young, M; Walls, M; Hughes, R; Kurinij, N; Mowery, RL; Alston, B; Foulkes, M; Jabs, DA; Davis, MD; Kurinij, N; Meinert, CL; Mowery, RL; Jabs, DA; Addessi, A; Alston, B; Clark, T; Davis, MD; Feinberg, J; Freeman, W; Holbrook, J; Holland, GN; Hubbard, L; Jacobson, M; Kurinij, N; Lewis, RA; McArthur-Chang, L; Meinert, C; Mowery, R; Murphy, R; Polsky, B; Tonascia, J; Jabs, DA; Davis, MD; Duncan, WR; Feinberg, J; Kessler, H; Kurinij, N; Lambert, AG; Meinert, CL; Mowery, RL; Powderly, W; Schnittman, S; Spector, S; Tonascia, J; Brown, BW; Conway, B; Grizzle, J; Nussenblatt, R; Phair, JP; Smith, H; Whitley, R; Alston, B; Davis, MD; Foulkes, M; Jabs, DA; Kurinij, N; Meinert, CL; Mowery, RL; Tonascia, J; Jabs, DA; Freeman, WR; Jacobson, M; Murphy, R; Van Natta, ML; Meinert, CL; Cheng, B; Frost, K; Lambert, AG; Marco, M;
Indirizzi:
Baylor Coll Med, Cullen Eye Inst, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 llen Eye Inst, Houston, TX 77030 USA Johns Hopkins Univ, Sch Med, Baltimore, MD USA Johns Hopkins Univ Baltimore MD USA ins Univ, Sch Med, Baltimore, MD USA Louisiana State Univ, Med Ctr, New Orleans, LA USA Louisiana State Univ New Orleans LA USA iv, Med Ctr, New Orleans, LA USA Mt Sinai Sch Med, New York, NY USA Mt Sinai Sch Med New York NY USAMt Sinai Sch Med, New York, NY USA New Jersey Med Sch, Newark, NJ 07103 USA New Jersey Med Sch Newark NJ USA07103 rsey Med Sch, Newark, NJ 07103 USA NYU, Med Ctr, New York, NY 10016 USA NYU New York NY USA 10016NYU, Med Ctr, New York, NY 10016 USA Northwestern Univ, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA60611 estern Univ, Chicago, IL 60611 USA Univ Calif Los Angeles, Los Angeles, CA USA Univ Calif Los Angeles Los Angeles CA USA s Angeles, Los Angeles, CA USA Univ Calif San Diego, San Diego, CA 92103 USA Univ Calif San Diego San Diego CA USA 92103 iego, San Diego, CA 92103 USA Univ Calif San Francisco, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Miami, Sch Med, Miami, FL USA Univ Miami Miami FL USAUniv Miami, Sch Med, Miami, FL USA Univ N Carolina, Chapel Hill, NC USA Univ N Carolina Chapel Hill NC USAUniv N Carolina, Chapel Hill, NC USA Univ S Florida, Tampa, FL USA Univ S Florida Tampa FL USAUniv S Florida, Tampa, FL USA Johns Hopkins Univ, Sch Hyg & Publ Hlth, Coordinating Ctr, Baltimore, MD USA Johns Hopkins Univ Baltimore MD USA Coordinating Ctr, Baltimore, MD USA Univ Wisconsin, Fundus Photograph Reading Ctr, Madison, WI USA Univ Wisconsin Madison WI USA us Photograph Reading Ctr, Madison, WI USA McKesson Bioserv Corp, Drug Distribut Ctr, Rockville, MD USA McKesson Bioserv Corp Rockville MD USA Distribut Ctr, Rockville, MD USA NEI, Bethesda, MD 20892 USA NEI Bethesda MD USA 20892NEI, Bethesda, MD 20892 USA NIAID, Bethesda, MD 20892 USA NIAID Bethesda MD USA 20892NIAID, Bethesda, MD 20892 USA
Titolo Testata:
AIDS
fascicolo: 11, volume: 14, anno: 2000,
pagine: 1571 - 1581
SICI:
0269-9370(20000728)14:11<1571:LFOPWA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; COMBINATION ANTIRETROVIRAL THERAPY; RELEASE GANCICLOVIR IMPLANT; INTRAVENOUS CIDOFOVIR; MAINTENANCE THERAPY; NUCLEOTIDE ANALOG; NATURAL-HISTORY; (S)-1-<3-HYDROXY-2-(PHOSPHONYLMETHOXY)PROPYL>CYTOSINE; INFECTION; DISEASE;
Keywords:
AIDS; cidofovir; cytomegalovirus retinitis; nephrotoxicity; uveitis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Jabs, DA 550 N Broadway,Suite 700, Baltimore, MD 21205 USA 550 N Broadway,Suite 700 Baltimore MD USA 21205 re, MD 21205 USA
Citazione:
R.A. Lewis et al., "Long-term follow-up of patients with AIDS treated with parenteral cidofovir for cytomegalovirus retinitis: the HPMPC Peripheral Cytomegalovirus Retinitis Trial - The Studies of Ocular Complications of AIDS Research Group in collaboration with the AIDS Clinical Trials Group", AIDS, 14(11), 2000, pp. 1571-1581

Abstract

Objective: To evaluate patients with cytomegalovirus (CMV) retinitis treated with intravenous cidofovir for long-term outcomes. Design: Patients with CMV retinitis enrolled in a randomized, controlled clinical trial of intravenous cidofovir as treatment for retinitis were followed for long-term outcomes, including 21 patients initially enrolled in the deferral group who received cidofovir therapy after progression of retinitis. Setting: Thirteen tertiary care clinics specializing in AIDS care and ophthalmology. Participants: Fifty-eight patients with AIDS and small peripheral CMV retinitis lesions. Interventions: Cidofovir 5 mg/kg once weekly for 2 weeks followed by low-dose maintenance cidofovir therapy (3 mg/kg) in 35 patients or high-dose maintenance (5 mg/kg) in 23 patients. Main outcome measures: Time to progression of retinitis, drug toxicities. Results: Median time to progression of retinitis was 2.5 months. Median time to discontinuation of cidofovir because of intolerance was 6.6 months, and did not differ significantly between the two maintenance doses. Median time to discontinuation of cidofovir for intolerance other than probenecid reaction was 16.3 months for patients treated with low-dose maintenance and 5.0 months for patients treated with high-dose maintenance (P = 0.021). Proteinuria of 2+ or more occurred at a rate of 1.22/person year. In patients with sufficient follow-up to determine resolution of proteinuria, 89.9% of episodes resolved, and the median time to resolution was 20 days. Rates of probenecid intolerance and of cidofovir-associated uveitis were 0.35/person-year, and 0.20/person-year, respectively.

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Documento generato il 02/07/20 alle ore 19:13:46