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Titolo:
Prevention of pleuropneumonia in pigs by in-feed medication with sulphadimethoxine and sulphamethoxazole in combination with trimethoprim
Autore:
Mengelers, MJB; Kuiper, HA; Pijpers, A; Verheijden, JHM; van Miert, ASJPAM;
Indirizzi:
Univ Utrecht, Fac Vet Med, Dept Farm Anim Hlth, NL-3584 CL Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3584 CL 3584 CL Utrecht, Netherlands State Inst Qual Control Agr Prod, Dept Toxicol, Wageningen, Netherlands State Inst Qual Control Agr Prod Wageningen Netherlands en, Netherlands
Titolo Testata:
VETERINARY QUARTERLY
fascicolo: 3, volume: 22, anno: 2000,
pagine: 157 - 162
SICI:
0165-2176(200007)22:3<157:POPIPB>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA-PROTEIN BINDING; INFECTION ACTINOBACILLUS-PLEUROPNEUMONIAE; TISSUE PENETRATION; ALPHA(1)-ACID GLYCOPROTEIN; MAIN METABOLITES; SULFADIMETHOXINE; SULFAMETHOXAZOLE; PHARMACOKINETICS; SULFONAMIDE; ANTIBIOTICS;
Keywords:
preventive usage; pleuropneumonia; pigs; feed; sulphonamides; trimethoprim;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: van Miert, ASJPAM Univ Utrecht, Fac Vet Med, Div Pharmacol Pharm & Toxicol, POB 80152, NL-3508 TD Utrecht, Netherlands Univ Utrecht POB 80152 Utrecht Netherlands NL-3508 TD s
Citazione:
M.J.B. Mengelers et al., "Prevention of pleuropneumonia in pigs by in-feed medication with sulphadimethoxine and sulphamethoxazole in combination with trimethoprim", VET Q, 22(3), 2000, pp. 157-162

Abstract

The prophylactic effect of in-feed medication of conventional pigs with sulphadimethoxine (SDM), sulphamethoxazole (SMX), and trimethoprim (TMP) was tested by using an Actinobacillus pleuropneumoniae infection model. In eachof five experiments, six pigs were given medicated feed twice daily and three pigs received antibiotic-free feed and served as positive (unmedicated,infected) controls. The following drugs or drug combinations were tested (in mg per kg feed): 500 SDM + 100 TIMP, 500 SMX + 100 TMP, 125 SMX + 25 TMP, 125 SMX (alone) and 25 TMP (alone), After six days of feed medication, all animals were endobronchially inoculated with A. pleuropneumoniae in a dose of 1-3.10(4) colony-forming units (CFU), The response to the challenge inall control pigs was characterized by fever, lethargy, anorexia, reduced water consumption, and laboured breathing. At autopsy all controls manifested a fibrinous haemorrhagic pleuropneumonia, In-feed medication with 500 SDM+ 100 TMP, 500 SMX + 100 TMP as well as 125 SMX + 25 TMP resulted in an effective protection against the challenge in all treated animals. After consumption of feed medicated with 125 mg per kg SMX or 25 mg per kg TMP, pleuropneumonia was evident in all challenged pigs, The results of this study indicate an in vivo potentiation of SMX and TMP in pigs against this respiratory tract pathogen.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 04:32:31