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Titolo:
Genotypic patterns of multiple isolates of M-tuberculosis from tuberculousHIV patients
Autore:
Lourenco, MCS; Grinsztejn, B; Fandinho-Montes, FCO; da Silva, MG; Saad, MHF; Fonseca, LS;
Indirizzi:
Univ Fed Rio de Janeiro, Ctr Ciencias Saude, Inst Microbiol, BR-21941590 Rio De Janeiro, Brazil Univ Fed Rio de Janeiro Rio De Janeiro Brazil BR-21941590 BCeiro, Brazil FIOCRUZ, Hosp Evandro Chagas, BR-21045900 Rio De Janeiro, Brazil FIOCRUZ Rio De Janeiro Brazil BR-21045900 BC45900 Rio De Janeiro, Brazil FIOCRUZ, Inst Desenvolvimento Tecnol & Prod Imunobiol, BR-21045900 Rio De Janeiro, Brazil FIOCRUZ Rio De Janeiro Brazil BR-21045900 BC45900 Rio De Janeiro, Brazil FIOCRUZ, Inst Oswaldo Cruz, Lab Hanseniase, BR-21045900 Rio De Janeiro, Brazil FIOCRUZ Rio De Janeiro Brazil BR-21045900 BC45900 Rio De Janeiro, Brazil
Titolo Testata:
TROPICAL MEDICINE & INTERNATIONAL HEALTH
fascicolo: 7, volume: 5, anno: 2000,
pagine: 488 - 494
SICI:
1360-2276(200007)5:7<488:GPOMIO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; RESISTANT MYCOBACTERIUM-TUBERCULOSIS; FRAGMENT-LENGTH-POLYMORPHISM; EXOGENOUS REINFECTION; PULMONARY TUBERCULOSIS; INFECTED PATIENTS; TRANSMISSION; EPIDEMIOLOGY; AIDS; MORTALITY;
Keywords:
tuberculosis; HIV coinfection; multiple isolates; genotypic patterns;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Fonseca, LS Univ Fed Rio de Janeiro, Ctr Ciencias Saude, Inst Microbiol, Bloco I,Ilha Fundao, BR-21941590 Rio De Janeiro, Brazil Univ Fed Rio de Janeiro Bloco I,Ilha Fundao Rio De Janeiro Brazil BR-21941590 BC
Citazione:
M.C.S. Lourenco et al., "Genotypic patterns of multiple isolates of M-tuberculosis from tuberculousHIV patients", TR MED I H, 5(7), 2000, pp. 488-494

Abstract

We investigated whether the recurrence of tuberculosis in HIV-infected patients is due to an exogenous reinfection or relapses after antituberculosischemotherapy. We reviewed clinical information on 32 patients at a Rio de Janeiro hospital from whom multiple Mycobacterium tuberculosis isolates were taken. All isolates were analysed by DRE-PCR fingerprinting technique, and those with identical DRE-PCR patterns were analysed by the RFLP method. Twenty patients had M. tuberculosis simultaneously isolated from different organs. These patients and nine others with sequential positive cultures after 2 months of therapy showed stable DRE-PCR and RFLP patterns. One patient's isolate became resistant to isoniazid, but the molecular pattern remained unchanged despite the development of drug resistance. in three patients, the DRE-PCR patterns of the isolates changed dramatically. Clinical and microbiological evidence was consistent with active tuberculosis caused by a new strain of M. tuberculosis. The exogenous reinfection of the three patients was not due to an outbreak, but the isolates from each patient showed unique patterns.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 21:48:07