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Titolo:
Effects of neonatal axoplasmic transport attenuation on the response properties of vibrissae-sensitive neurons in the trigeminal principal sensory nucleus of the rat
Autore:
Chiaia, NL; Zhang, S; Crissman, RS; Rhoades, RW;
Indirizzi:
Med Coll Ohio, Dept Anat & Neurobiol, Toledo, OH 43614 USA Med Coll Ohio Toledo OH USA 43614 Anat & Neurobiol, Toledo, OH 43614 USA
Titolo Testata:
SOMATOSENSORY AND MOTOR RESEARCH
fascicolo: 3, volume: 17, anno: 2000,
pagine: 273 - 283
SICI:
0899-0220(200009)17:3<273:EONATA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFRAORBITAL NERVE-SECTION; POSTERIOR MEDIAL THALAMUS; BARREL CORTEX; BRAIN-STEM; SUBNUCLEUS INTERPOLARIS; FUNCTIONAL CONSEQUENCES; AWAKE RATS; ORGANIZATION; CAPSAICIN; WHISKER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Chiaia, NL Med Coll Ohio, Dept Anat & Neurobiol, POB 10008, Toledo, OH 43614 USA Med Coll Ohio POB 10008 Toledo OH USA 43614 oledo, OH 43614 USA
Citazione:
N.L. Chiaia et al., "Effects of neonatal axoplasmic transport attenuation on the response properties of vibrissae-sensitive neurons in the trigeminal principal sensory nucleus of the rat", SOMAT MOT R, 17(3), 2000, pp. 273-283

Abstract

We have previously shown that attenuation of axoplasmic transport by application of vinblastine to the developing infraorbital nerve (ION) results ina loss of central vibrissae-related patterns that is not accompanied by changes in the receptive field sizes for the V primary afferents innervating the whisker follicles. The present study examines the relationship between the loss of central vibrissae-related patterns and alterations in the response properties of neurons in the V principal sensory nucleus (PrV) of adultrats that sustained application of vinblastine to the ION at birth. Absence of histochemically demonstrable vibrissae-related patterns in PrV resulted in only modest changes in the receptive fields and response properties ofvibrissae-sensitive neurons in this nucleus that projected to the contralateral thalamus. Response latencies to electrical activation of the V ganglion were similar in treated and untreated animals. The mean receptive field size was significantly increased from 1.3 +/- 0.7 vibrissae in controls to 1.7 +/- 0.9 vibrissae in vinblastine-treated animals, and the percentage ofcells yielding a tonic response to vibrissae deflection was markedly reduced (p < 0.01 for both measures). Phasically responding cells recorded in vinblastine-treated animals showed a significant reduction in the mean numberof spikes per stimulus following deflection of the vibrissae in either thepreferred or non-preferred direction relative to cells recorded in normal animals (p < 0.05). The present results indicate that disruption of the normal vibrissae-related aggregates of neurons in PrV by application of vinblastine to the ION has limited effects on the functional representation of the vibrissae in this nucleus.

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Documento generato il 26/09/20 alle ore 12:02:40