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Titolo:
C-fos expression in trigeminal spinal nucleus after electrical stimulationof the hypoglossal nerve in the rat
Autore:
Bereiter, DA; Bereiter, DF; Hirata, H; Hu, JW;
Indirizzi:
Brown Univ, Rhode Isl Hosp, Sch Med, Dept Neurosci, Providence, RI 02903 USA Brown Univ Providence RI USA 02903 ept Neurosci, Providence, RI 02903 USA Brown Univ, Rhode Isl Hosp, Sch Med, Dept Surg, Providence, RI 02903 USA Brown Univ Providence RI USA 02903 d, Dept Surg, Providence, RI 02903 USA Univ Toronto, Fac Dent, Toronto, ON M5G 1G6, Canada Univ Toronto Toronto ON Canada M5G 1G6 Dent, Toronto, ON M5G 1G6, Canada
Titolo Testata:
SOMATOSENSORY AND MOTOR RESEARCH
fascicolo: 3, volume: 17, anno: 2000,
pagine: 229 - 237
SICI:
0899-0220(200009)17:3<229:CEITSN>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDULLARY DORSAL HORN; HORSERADISH-PEROXIDASE; AFFERENT-FIBERS; ANTEROGRADE TRANSPORT; CHEMICAL-STIMULATION; PARABRACHIAL NUCLEUS; SUBSTANCE-P; LAMINA-I; NEURONS; PROJECTIONS;
Keywords:
hypoglossal nerve; immediate early gene; nociception; tongue; trigeminal system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Bereiter, DA Brown Univ, Rhode Isl Hosp, Sch Med, Dept Neurosci, Providence, RI 02903 USA Brown Univ Providence RI USA 02903 Providence, RI 02903 USA
Citazione:
D.A. Bereiter et al., "C-fos expression in trigeminal spinal nucleus after electrical stimulationof the hypoglossal nerve in the rat", SOMAT MOT R, 17(3), 2000, pp. 229-237

Abstract

The expression of the immediate early gene, c-fos, was used to determine the distribution of brainstem neurons activated by stimulation of the distalhypoglossal nerve (XIIn) trunk. The traditional view of the XIIn is one ofpurely motor function; however, stimulation of XIIn excites neurons in thetrigeminal spinal nucleus. The rationale for this study was to use c-fos expression as a marker for postsynaptic activity to define the pattern of brainstem neurons excited by XIIn stimulation. It was further hypothesized that if the afferent fibers that course within XIIn supply deep lingual tissues, then c-fos expression after direct stimulation of XIIn should display apattern similar to that seen after chemical irritant stimulation of the deep tongue muscle. In barbiturate-anesthetized male rats electrical stimulation of XIIn produced a significant increase in Fos-positive neurons in the dorsal paratrigeminal nucleus (dPa5) and laminae I-II of caudal subnucleus caudalis (Vc) and upper cervical dorsal horn. Mustard oil injection into the deep tongue muscle also produced an increase in c-fos expression in dPa5;however, the highest density of expression occurred in laminae I-II at thedorsomedial aspect of rostral Vc. Both electrical stimulation of XIIn and mustard oil stimulation of the deep tongue increased c-fos expression in the caudal ventrolateral medulla, an autonomic relay nucleus. These results suggest that one site of innervation for afferent fibers that travel within the distal trunk of XIIn is to supply the deep tongue muscle and to terminate in the dPa5. A second group of postsynaptic neurons activated only by XIIn stimulation was located in lamina I-II in caudal portions of Vc and upper cervical dorsal horn, a laminar distribution consistent with a role for XIIn afferents in sensory or autonomic aspects of lingual function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 23:11:13