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Titolo:
CENTRAL ROLE OF VASCULAR SMOOTH-MUSCLE HYPERREACTIVITY IN CORONARY HYPERCONSTRICTION AFTER BALLOON INJURY IN MINIATURE PIGS
Autore:
KUGA T; KADOKAMI T; KUWATA K; HATA H; OHARA Y; EGASHIRA K; SHIMOKAWA H; TAKESHITA A;
Indirizzi:
KYUSHU UNIV,SCH MED,ANGIOCARDIOL RES INST,HIGASHI KU,FAC MED,3-1-1 MAIDASHI FUKUOKA 81282 JAPAN KYUSHU UNIV,SCH MED,ANGIOCARDIOL RES INST,HIGASHI KU,FAC MED FUKUOKA 81282 JAPAN
Titolo Testata:
Coronary artery disease
fascicolo: 2, volume: 8, anno: 1997,
pagine: 69 - 75
SICI:
0954-6928(1997)8:2<69:CROVSH>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERY SPASM; EXPERIMENTAL ANGIOPLASTY; VARIANT ANGINA; SWINE MODEL; ENDOTHELIUM; SEROTONIN; RESPONSIVENESS; RESTENOSIS; MECHANISMS; SITE;
Keywords:
CORONARY SPASM; SEROTONIN; ENDOTHELIUM; ENDOTHELIUM-DEPENDENT RELAXATION; CORONARY ARTERY; MYOCARDIAL ISCHEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
T. Kuga et al., "CENTRAL ROLE OF VASCULAR SMOOTH-MUSCLE HYPERREACTIVITY IN CORONARY HYPERCONSTRICTION AFTER BALLOON INJURY IN MINIATURE PIGS", Coronary artery disease, 8(2), 1997, pp. 69-75

Abstract

Background Coronary constrictive responses to autacoids become augmented 1 week after balloon injury in our swine model. The present study aimed to elucidate the mechanisms of this effect. Methods In 12 hypercholesterolaemic miniature pigs, the coronary constrictive response to serotonin was examined angiographically 1 week after injury, After theangiographic study, organ chamber experiments using excised coronary artery were performed to clarify whether functional changes in endothelial cells or in Vascular smooth muscle cells contributed to the hyperconstriction. Results The coronary constrictive response to serotonin in vivo was significantly greater at the previously injured site than at the non-injured site. The degree of the hyperconstriction at the previously injured site exceeded that predicted from a geometric theory,Histological examination demonstrated that the previously injured site was almost covered with regenerated endothelial cells. In vitro studies demonstrated that serotonin caused significantly greater contraction in coronary artery strips, whether with or without endothelium, from the previously injured site than in those from the non-injured site. Endothelium-dependent relaxation in response to serotonin was comparable at the injured and non-injured sites. Conclusions These results suggest that the coronary hyperconstriction response to serotonin 1 weekafter injury results primarily from hyperreactivity of vascular smooth muscle, Whereas any contribution of endothelial dysfunction or the geometric effect may be minimal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:50:47