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Titolo:
Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies
Autore:
Vanderschuren, LJMJ; Kalivas, PW;
Indirizzi:
Free Univ Amsterdam, Fac Med, Dept Pharmacol, Res Inst Neurosci,Drug AbuseProgram, NL-1081 BT Amsterdam, Netherlands Free Univ Amsterdam Amsterdam Netherlands NL-1081 BT terdam, Netherlands Med Univ S Carolina, Dept Physiol & Neurosci, Charleston, SC 29425 USA MedUniv S Carolina Charleston SC USA 29425 sci, Charleston, SC 29425 USA
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2-3, volume: 151, anno: 2000,
pagine: 99 - 120
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; MEDIAL PREFRONTAL CORTEX; RAT NUCLEUS-ACCUMBENS; FREELY MOVING RATS; CONDITIONED PLACE PREFERENCE; IBOTENIC ACID LESIONS; AMPHETAMINE ADMINISTRATION ALTERS; INDUCED LOCOMOTOR-ACTIVITY; LONG-TERM SENSITIZATION; EXCITATORY AMINO-ACIDS;
Keywords:
behavioral sensitization; locomotor activity; dopamine; glutamate; ventral tegmental area; nucleus accumbens; prefrontal cortex; drug addiction;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
318
Recensione:
Indirizzi per estratti:
Indirizzo: Vanderschuren, LJMJ Free Univ Amsterdam, Fac Med, Dept Pharmacol, Res InstNeurosci,Drug AbuseProgram, Van der Boechorststr 7, NL-1081 BT Amsterdam, Netherlands Free Univ Amsterdam Van der Boechorststr 7 Amsterdam Netherlands NL-1081 BT
Citazione:
L.J.M.J. Vanderschuren e P.W. Kalivas, "Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies", PSYCHOPHAR, 151(2-3), 2000, pp. 99-120

Abstract

Rationale and objectives: Repeated exposure to many drugs of abuse resultsin a progressive and enduring enhancement in the motor stimulant effect elicited by a subsequent drug challenge. This phenomenon, termed behavioral sensitization, is thought to underlie certain aspects of drug addiction. Behavioral sensitization is the consequence of drug-induced neuroadaptive changes in a circuit involving dopaminergic and glutamatergic interconnections between the ventral tegmental area, nucleus accumbens, prefrontal cortex and amygdala. Methods: The literature was critically reviewed in an effort todiscern the relative roles of glutamate and dopamine transmission in the induction and expression of sensitization to amphetamine, cocaine and mu-opioids. In addition, the literature was reviewed to evaluate distinctions between these drugs in the involvement of the relevant brain nuclei listed above. Results: The common substrates between sensitizing drugs are glutamate transmission, especially at the NMDA receptor, and an action in the ventraltegmental area. In contrast, a role for dopamine is only clearly seen in amphetamine sensitization and critical involvement of nuclei outside the ventral tegmental area is found for cocaine and morphine. While enhanced dopamine transmission is associated with sensitization by all three drugs, a role for glutamate is clearly identified only with cocaine sensitization. Accordingly, glutamatergic cortical and allocortical brain regions such as the prefrontal cortex appear more critical for cocaine sensitization. Conclusions: The distinctions between drugs in the induction and expression of sensitization indicate that behavioral sensitization can arise from multiple neuroadaptations in multiple brain nuclei. This is not only I:he result of distinct molecular targets for the drugs, but may also include a differential involvement of learned associations. It is postulated that the relatively more robust pharmacological capacity of amphetamine to release dopamine may induce a form of sensitization that is more dependent on adaptations in mesoaccumbens dopamine transmission compared with cocaine and morphine sensitization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:36:57