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Titolo:
Risperidone versus clozapine in treatment-resistant schizophrenia: A randomized pilot study
Autore:
Wahlbeck, K; Cheine, M; Tuisku, K; Ahokas, A; Joffe, G; Rimon, R;
Indirizzi:
Univ Helsinki, Dept Psychiat, FIN-00029 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00029 at, FIN-00029 Helsinki, Finland
Titolo Testata:
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
fascicolo: 6, volume: 24, anno: 2000,
pagine: 911 - 922
SICI:
0278-5846(200008)24:6<911:RVCITS>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTROLLED TRIALS; SCALE;
Keywords:
antipsychotic agents; clozapine; randomized controlled trials; risperidone; schizophrenia; treatment outcome;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Wahlbeck, K Univ Helsinki, Dept Psychiat, Lappviksvagen,PB 320, FIN-00029 Helsinki, Finland Univ Helsinki Lappviksvagen,PB 320 Helsinki Finland FIN-00029
Citazione:
K. Wahlbeck et al., "Risperidone versus clozapine in treatment-resistant schizophrenia: A randomized pilot study", PROG NEUR-P, 24(6), 2000, pp. 911-922

Abstract

1. The atypical antipsychotic risperidone may constitute an alternative toclozapine, the current treatment of choice for refractory schizophrenia. The objectives of this study were to evaluate the effectiveness of risperidone in comparison to clozapine in everyday practice and to assess the feasibility of a pragmatic trial procedure.2. Patients were randomly assigned to open-label clozapine or risperidone treatment for 10 weeks and treatment outcomes were assessed blindly. Twenty-one patients were recruited and nineteen entered the randomized phase.3. Five of 10 participants allocated to clozapine and one of nine risperidone participants dropped out before study completion. Five clozapine patients and six risperidone patients achieved clinical improvement, defined as a20% decrease in the Positive and Negative Symptom Scale (PANSS) total score. No significant differences between the groups were detected iii baselineor endpoint positive or negative symptoms, disease severity, or global or social functioning scores. Patients' opinion on the drugs did not differ between groups.4. The findings of the intention-to-treat analysis of this study corroborates previous findings that risperidone may be equally effective as clozapine, and supports the feasibility and need of a multicenter randomized pragmatic trial with sufficient power to detect differences between treatments.

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Documento generato il 30/03/20 alle ore 19:45:38