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Titolo:
The basic helix-loop-helix transcription factor capsulin controls spleen organogenesis
Autore:
Lu, JR; Chang, P; Richardson, JA; Gan, L; Weiler, H; Olson, EN;
Indirizzi:
Blood Res Inst, Milwaukee, WI 53226 USA Blood Res Inst Milwaukee WI USA 53226 d Res Inst, Milwaukee, WI 53226 USA Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 d Ctr, Dept Mol Biol, Dallas, TX 75235 USA Univ Texas, SW Med Ctr, Dept Pathol, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 Med Ctr, Dept Pathol, Dallas, TX 75235 USA Univ Texas, MD Anderson Canc Ctr, Dept Biochem & Mol Biol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 Biochem & Mol Biol, Houston, TX 77030 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 17, volume: 97, anno: 2000,
pagine: 9525 - 9530
SICI:
0027-8424(20000815)97:17<9525:TBHTFC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE; DROSOPHILA; MESENCHYME; EPICARDIUM; MESODERM; BAGPIPE; ORGANS; MUSCLE; KIDNEY; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Olson, EN Blood Res Inst, 8227 Watertown Plank Rd, Milwaukee, WI 53226 USABlood Res Inst 8227 Watertown Plank Rd Milwaukee WI USA 53226 SA
Citazione:
J.R. Lu et al., "The basic helix-loop-helix transcription factor capsulin controls spleen organogenesis", P NAS US, 97(17), 2000, pp. 9525-9530

Abstract

Formation of numerous internal organs involves reciprocal epithelial-mesenchymal signaling and subsequent patterning and growth of the organ primordium. Capsulin is a basic helix-loop-helix transcription factor expressed in mesenchymal cells that encapsulate the epithelial primordia of internal organs, including the kidney and lung, as well as the epicardium, which gives rise to the coronary arteries. Capsulin is also expressed in the mesothelium that gives rise to the spleen. We demonstrate that mice homozygous for a capsulin null mutation fail to form a spleen. The homeobox genes Hox11 and Bapx1, shown previously to be essential regulators of spleen organogenesis,and a lacZ reporter introduced into the capsulin locus, were expressed in the early splenic primordium, derived from the splanchnic mesoderm, of homozygous mutant embryos. However, this primordium failed to develop beyond aninitial group of precursor cells and underwent rapid apoptosis. The phenotype of capsulin mutant mice demonstrates that capsulin acts within a subpopulation of splanchnic mesodermal cells to control an essential early step in spleen organogenesis that is likely to represent a point of regulatory convergence of the capsulin, Hox11, and Bapx1 genes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:36:32